Vicenin 2(Synonyms: 维采宁 2)

天然产物 黄酮类 Flavonoids

Vicenin 2 (Synonyms: 维采宁 2) 纯度: 99.31%

Vicenin 2 来自广金钱草 (Desmodium styracifolium) 的地上部分。Vicenin 2 是一种血管紧张素转换酶 (ACE) 抑制剂,IC50 为 43.83 μM。

Vicenin 2(Synonyms: 维采宁 2)

Vicenin 2 Chemical Structure

CAS No. : 23666-13-9

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10 mg ¥4000 In-stock
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Vicenin 2 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Metabolism/Protease Compound Library
  • Natural Product Library
  • Anti-Cardiovascular Disease Compound Library
  • Phenols Library
  • Traditional Chinese Medicine Monomer Library
  • Flavonoids Library
  • Angiogenesis Related Compound Library
  • Food-Sourced Compound Library

生物活性

Vicenin 2 is an angiotensin-converting enzyme (ACE) inhibitor (IC50=43.83 μM) from the aerial parts of Desmodium styracifolium[1].

分子量

594.52

Formula

C27H30O15

CAS 号

23666-13-9

中文名称

维采宁 2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 100 mg/mL (168.20 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (ultrasonic) (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6820 mL 8.4101 mL 16.8203 mL
5 mM 0.3364 mL 1.6820 mL 3.3641 mL
10 mM 0.1682 mL 0.8410 mL 1.6820 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.21 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.21 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.21 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (4.21 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献
  • [1]. Zhang YQ, et al. Bioassay-guided preparative separation of angiotensin-converting enzyme inhibitory C-flavone glycosides from Desmodium styracifolium by recycling complexation high-speed counter-current chromatography. J Pharm Biomed Anal. 2015 Jan;102:276-81.

Vicenin-1(Synonyms: 维采宁 1)

天然产物 黄酮类 Flavonoids

Vicenin-1 (Synonyms: 维采宁 1) 纯度: 95.92%

Vicenin 1 是一种糖基黄酮,对血管紧张素转换酶 (ACE) 有抑制作用,(IC50=52.50 μM)。

Vicenin-1(Synonyms: 维采宁 1)

Vicenin-1 Chemical Structure

CAS No. : 35927-38-9

规格 价格 是否有货 数量
5 mg ¥6800 In-stock
10 mg ¥11500 In-stock
50 mg   询价  
100 mg   询价  

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Vicenin-1 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

生物活性

Vicenin 1 is a C-glycosylflavone that has an inhibitory effect on angiotensin-converting enzyme (ACE)(IC50=52.50 μM)[1].

IC50 & Target

IC50: 52.50 μM (ACE)[1]

体外研究
(In Vitro)

The target-isolated C-glycosylflavone (Vicenin 1) is evaluated for inhibitory activities. Vicenin 1 embodies effective ACE inhibitory activities with an IC50 value of 52.50 μM. The tested compound 3 (Vicenin 1) shows activity via the generation of chelate complexes within the active center of ACE[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

564.49

Formula

C26H28O14

CAS 号

35927-38-9

中文名称

维采宁 1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. Zhang YQ, et al. Bioassay-guided preparative separation of angiotensin-converting enzyme inhibitory C-flavone glycosides from Desmodium styracifolium by recycling complexation high-speed counter-current chromatography. J Pharm Biomed Anal. 2015 Jan;102:276-81.

Vicenin 3(Synonyms: 维采宁 3)

天然产物 糖类和糖苷 Saccharides and Glycosides

Vicenin 3;(Synonyms: 维采宁 3) 纯度: 98.57%

Vicenin 3 来自广金钱草 (Desmodium styracifolium) 的地上部分。Vicenin 3 是一种血管紧张素转换酶 (ACE) 抑制剂,IC50 为 46.91 μM。

Vicenin 3(Synonyms: 维采宁 3)

Vicenin 3 Chemical Structure

CAS No. : 59914-91-9

规格 价格 是否有货 数量
5 mg ¥2350 In-stock
10 mg ¥4000 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Vicenin 3 相关产品

bull;相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Metabolism/Protease Compound Library
  • Natural Product Library
  • Anti-Cardiovascular Disease Compound Library
  • Phenols Library
  • Flavonoids Library
  • Angiogenesis Related Compound Library
  • Food-Sourced Compound Library

生物活性

Vicenin 3 is an angiotensin-converting enzyme (ACE) inhibitor (IC50=46.91 μM) from the aerial parts of Desmodium styracifolium[1].

分子量

564.49

Formula

C26H28O14

CAS 号

59914-91-9

中文名称

维采宁 3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4deg;C, sealed storage, away from moisture and light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)

参考文献
  • [1]. Zhang YQ, et al. Bioassay-guided preparative separation of angiotensin-converting enzyme inhibitory C-flavone glycosides from Desmodium styracifolium by recycling complexation high-speed counter-current chromatography. J Pharm Biomed Anal. 2015 Jan;102:276-81.