标签归档：grki

GRK2i TFA

发表于由

GRK2i TFA; 纯度: 98.13%

GRK2i TFA is a GRK2 inhibitory polypeptide that specifically inhibitsGβγ activation of GRK2. GRK2i TFA corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist.

GRK2i TFAamp;;

GRK2i TFA Chemical Structure

规格 价格 是否有货 数量
5 mg ￥5200 In-stock
10 mg ￥8500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

GRK2i TFA is a GRK2 inhibitory polypeptide that specifically inhibitsGβγ activation of GRK2. GRK2i TFA corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist.

分子量

3598.10

Formula

C152H257F3N50O43S
Sequence Shortening

WKKELRDAYREAQQLVQRVPKMKNKPRS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 100 mg/mL (27.79 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.2779 mL 1.3896 mL 2.7792 mL
5 mM 0.0556 mL 0.2779 mL 0.5558 mL
10 mM 0.0278 mL 0.1390 mL 0.2779 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Jorge A Sierra-Fonseca, et al. Nerve growth factor induces neurite outgrowth of PC12 cells by promoting Gβγ-microtubule interaction. BMC Neurosci. 2014 Dec 31;15:132.

GRK2i

发表于由

GRK2i;

GRK2i 是一种 Gβγ 抑制肽，可选择性地阻止 Gβγ 介导的信号传导。GRK2i 对应于 GRK2（G 蛋白偶联受体激酶 2）的 Gβγ 结合域。

GRK2iamp;;

GRK2i Chemical Structure

CAS No. : 148505-03-7

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

GRK2i is a Gβγ-inhibitory peptide that selectively prevents Gβγ-mediated signaling. GRK2i corresponds to the Gβγ-binding domain of GRK2 (G-protein-coupled receptor kinase 2)[1].

IC50 Target

Gβγ
体外研究
(In Vitro)

GRK2i (5 μM) inhibits neurite formation, disrupts microtubules, and induces neurite damag in PC12 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

3484.08

Formula

C153H256N50O41S
CAS 号

148505-03-7
Sequence Shortening

WKKELRDAYREAQQLVQRVPKMKNKPRS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jorge A Sierra-Fonseca, et al. Nerve growth factor induces neurite outgrowth of PC12 cells by promoting Gβγ-microtubule interaction. BMC Neurosci. 2014 Dec 31;15:132.