Wako Biostir-过敏性皮炎诱发试剂Biostir AD、研究用过敏原


Wako Biostir-过敏性皮炎诱发试剂Biostir AD、研究用过敏原

Biostir AD 是与人类过敏性皮炎发病有关的含有粉尘螨虫体成分的软膏。同时,作为研究用过敏原,有来源于植物的过敏原和来源于昆虫的过敏原系列。


Biostir AD

用来源于粉尘螨的过敏性皮炎诱发软膏,为 NC/Nga 小鼠一周涂抹2次,共涂抹6次,第1~2周过敏性皮炎发病。



◆特点


● 可引发类似于过敏性皮炎的症状

● 可确认现在治疗时使用的甾族化合物软膏及专业软膏的效果

● 皮炎发病后,中止诱发,皮炎仍持续,可作为医药品的评价系使用

● 在小鼠标背部的逗留性优秀,少量就能诱发皮炎

● 皮炎的发病率高,无反应的小鼠极少

● 皮炎发病时间比之前方法(抗原液的反复涂抹)短



◆诱发方法


用 4% SDS 破坏皮肤防御后,向小鼠背部及耳廓部进行一周2次,每次涂抹 100 mg/mouse 本品。诱发期间的目标是3周(共计6次)。最终共计涂抹 600 mg 本品。模型动物表现涂药开始后,第 1~2 周发病,3~4 周约80%的发病率。

Wako Biostir-过敏性皮炎诱发试剂Biostir AD、研究用过敏原



◆产品列表

产品编号

产品名称

包装

参考

309-34133

Biostir AD

5 g

——

303-34131

15g

约25只的用量

307-34134

30 g

——



其他产品系列:来源于植物的过敏原和来源于昆虫的过敏原等


种类

产品编号

产品名称

包装

306-34143

Mite body

粉尘螨虫体(Dermatophagoides farinae)

1g

300-34141

2 g

308-35183

Mite body Dp

屋尘螨虫体(Dermatophagoides pteronyssinus)

1 g

302-35181

2 g

303-34153

Mite extract Dfb

粉尘螨提取物

来源于粉尘螨虫体粗纯化的过敏原

50 mg

307-34151

100 mg

304-35163

Mite Extract Dpb

屋尘螨提取物

来源于屋尘螨虫体粗纯化的抗原(Dpb)

50 mg

308-35161

100 mg

300-34163

Mite extrtact Dff

粉尘螨排泄物提取物

来源于粉尘螨排泄物粗纯化的过敏原

50 mg

304-34161

100 mg

301-35173

Mite Extract Dpf

屋尘螨排泄物提取物

来源于屋尘螨排泄物粗纯化的抗原(Dpf)

50 mg

305-35171

100 mg

种类

产品编号

产品名称

包装

木本花粉

304-35141

Japanese cedar pollen

日本雪松花粉

5 g

301-35151

Japanese cedar pollen extract

日本雪松花粉提取物

100 mg

307-35153

50 mg

304-84611

Japanese cypress pollen

日本柏树花粉

5 g

309-89281

Japanease red pine pollen

日本赤松花粉

5 g

308-89131

Black pine pollen

日本黑松花粉

5 g

305-89141

Ginkgo pollen

银杏花粉

5 g

种类

产品编号

产品名称

包装

草本花粉

308-89251

Mugwort pollen

蒿花粉

1 g

306-89291

Solidago serotina pollen

一枝黄花花粉

1 g

305-89261

Japanese pampas grass pollem

日本芒草花粉

1 g

309-89161

Japanese hop pollen

日本路草花粉

1 g

种类

产品编号

产品名称

包装

昆虫

309-89301

Silk moth

家蚕(冻干粉碎虫体)

1g

304-89231

Periplaneta fuliginosa

黑胸大蠊(冻干粉碎虫体)

1g

302-89151

German cockroach

德国小蠊(冻干粉碎虫体)

1g

种类

产品编号

产品名称

包装

输入型花粉

307-89221

white birch pollen import

输入型白桦花粉

1g

300-89191

ryegrass pollen import

输入型黑麦草花粉

1g

303-89201

imothy pollen import

输入型梯牧草花粉

1g

300-89211

Tvernalgrass pollen import

输入型欧洲香草花粉

1g

306-89171

Dactylis glomerata pollen import

输入型野茅花粉

1g

303-89181

Ragweed pollen import

输入型美洲豚草花粉

1g



Biostir® 特应性皮炎诱导剂AD Biostir® AD

 Biostir® 特应性皮炎诱导剂AD

 

产品编号 产品名称 中文名称 包装 备注
309-34133 Biostir® AD Biostir® 特应性皮炎诱导剂AD 5 g 软膏包括来自粉尘螨的螨过敏原,-30℃
303-34131 Biostir® AD Biostir® 特应性皮炎诱导剂AD 15 g
项目 方法 动物
特应性皮炎模型服务和药理学测试  1. 在D粉尘螨具有高含量螨变应原的NC / Nga小鼠中通过Biostir® AD

诱导特应性皮炎样损伤。

2. 经皮致敏/免疫小鼠。

3. 高概率获得特应性皮炎模型。

4. 评估测试物质对疾病模型的效力。

5. 评价项目:症状评分,IgE,组织病理学,搔抓行为等。

小鼠
(NC/Nga)

 

◆特征

● 是特应性皮炎相关的房尘螨提取物成分之一

● Biostir® AD能够在NC/Nga小鼠诱导特应性皮炎样皮肤损伤

● 在该模型中观察到他克莫司软膏和皮质类固醇软膏的功效

● Biostir® AD能高概率在NC/Nga小鼠引起皮炎

● Biostir® AD节省时间和精力,与重复应用螨过敏原悬浮液相比较直到观察到皮炎发病

● 现今还没有类似概念的产品

 

◆操作流程

用 4% 十二烷基硫酸钠(SDS)破坏屏障后,每周两次在剃毛的背部皮肤和两耳廓部涂抹100 mg的AD。
重复此步骤3周。共涂抹6次完成。

 

◆应用实例

 

动物 雌性NC / Nga小鼠
 

特应性皮炎样皮肤损伤的临床方面

 

 

在皮肤上观察到搔抓行为,红斑,丘疹,鳞屑,疮痂和苔藓病变

 

组织学评价 损伤皮肤表现在真皮和表皮显著增厚,角化过度和角化不全。
在损伤小鼠中观察到包括肥大细胞和嗜酸性粒细胞在内的皮肤炎症细胞数量的增加。
损伤小鼠中总数和脱颗粒的肥大细胞的数量多于正常小鼠。
 

血清总IgE

 

 

显著升高

 

 

■ 7周龄无毛雄性小鼠用Biostir AD处理诱发皮炎模型

141573705409.png

形态学表现

■ 苏木精和曙红对皮肤组织(5 μm)染色(1:500)

141573705463.png

产品列表

产品编号 产品名称 产品规格 产品等级 备注
309-34133 Biostir® AD
Biostir®特应性皮炎诱导剂AD
5 g
303-34131 Biostir® AD
Biostir®特应性皮炎诱导剂AD
15 g

 

 

Biostir® 特应性皮炎诱导剂AD Biostir® AD

Biostir® 特应性皮炎诱导剂AD
Biostir® AD

  • 产品特性
  • 相关资料
  • Q&A
  • 参考文献

Biostir® 特应性皮炎诱导剂AD                              Biostir® AD

Biostir® 特应性皮炎诱导剂AD

 


产品编号

产品名称

中文名称

包装

备注

309-34133

Biostir® AD

Biostir® 特应性皮炎诱导剂AD

5 g

软膏包括来自粉尘螨的螨过敏原,-30℃

303-34131

Biostir® AD

Biostir® 特应性皮炎诱导剂AD

15 g

项目

方法

动物

特应性皮炎模型服务和药理学测试

 1. 在D粉尘螨具有高含量螨变应原的NC / Nga小鼠中通过Biostir® AD

     诱导特应性皮炎样损伤。

    
 2. 经皮致敏/免疫小鼠。
    
 3. 高概率获得特应性皮炎模型。
    
 4. 评估测试物质对疾病模型的效力。
    
 5. 评价项目:症状评分,IgE,组织病理学,搔抓行为等。

小鼠
(NC/Nga)



◆特征


 ● 是特应性皮炎相关的房尘螨提取物成分之一

 ● Biostir® AD能够在NC/Nga小鼠诱导特应性皮炎样皮肤损伤

 ● 在该模型中观察到他克莫司软膏和皮质类固醇软膏的功效

 ● Biostir® AD能高概率在NC/Nga小鼠引起皮炎

 ● Biostir® AD节省时间和精力,与重复应用螨过敏原悬浮液相比较直到观察到皮炎发病

 ● 现今还没有类似概念的产品

 


◆操作流程


  用 4% 十二烷基硫酸钠(SDS)破坏屏障后,每周两次在剃毛的背部皮肤和两耳廓部涂抹100 mg的AD。
  重复此步骤3周。共涂抹6次完成。



◆应用实例


动物

雌性NC / Nga小鼠


特应性皮炎样皮肤损伤的临床方面



在皮肤上观察到搔抓行为,红斑,丘疹,鳞屑,疮痂和苔藓病变


组织学评价

损伤皮肤表现在真皮和表皮显著增厚,角化过度和角化不全。
在损伤小鼠中观察到包括肥大细胞和嗜酸性粒细胞在内的皮肤炎症细胞数量的增加。
损伤小鼠中总数和脱颗粒的肥大细胞的数量多于正常小鼠。


血清总IgE



显著升高


■ 7周龄无毛雄性小鼠用Biostir AD处理诱发皮炎模型

Biostir® 特应性皮炎诱导剂AD                              Biostir® AD

形态学表现

■ 苏木精和曙红对皮肤组织(5 μm)染色(1:500)


Biostir® 特应性皮炎诱导剂AD                              Biostir® AD


参考文献


 1.

Kang, R. Y., Park, B. K., Gim, S. B., Choi, H. J., & Kim, D. H. (2009). The effects of HYT on various immunological factors related to pathogenesis of allergic dermatitis in NC/Nga mice induced by Biostir AD. Journal of Haehwa Medicine, 18(2), 47-62.


 2.

Lee, J. K., Ha, H., Lee, H. Y., Park, S. J., Jeong, S. L., Choi, Y. J., & SHIN, H. K. (2010). Inhibitory effects of heartwood extracts of Broussonetia kazinoki Sieb on the development of atopic dermatitis in NC/Nga mice. Bioscience, biotechnology, and biochemistry, 1007282075-1007282075.


 3.

Lim, H. S., Ha, H., Lee, H., Lee, J. K., Lee, M. Y., & Shin, H. K. (2014). Morus alba L. suppresses the development of atopic dermatitis induced by the house dust mite in NC/Nga mice. BMC complementary and alternative medicine, 14(1), 139.


 4.

Aktar, M. K., Kido‐Nakahara, M., Furue, M., & Nakahara, T. (2015). Mutual upregulation of endothelin‐1 and IL‐25 in atopic dermatitis. Allergy, 70(7), 846-854.

 5.

Joo, S. S., Won, T. J., Nam, S. Y., Kim, Y. B., Lee, Y. C., Park, S. Y., … & Lee, D. I. (2009). Therapeutic advantages of medicinal herbs fermented with Lactobacillus plantarum, in topical application and its activities on atopic dermatitis. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 23(7), 913-919.


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Lim, H. S., Seo, C. S., Ha, H., Lee, H., Lee, J. K., Lee, M. Y., & Shin, H. (2012). Effect of Alpinia katsumadai Hayata on house dust mite-induced atopic dermatitis in NC/Nga mice. Evidence-Based Complementary and Alternative Medicine, 2012.


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Lim, H. S., Ha, H., Lee, M. Y., Jin, S. E., Jeong, S. J., Jeon, W. Y., … & Shin, H. K. (2014). Saussurea lappa alleviates inflammatory chemokine production in HaCaT cells and house dust mite-induced atopic-like dermatitis in Nc/Nga mice. Food and chemical toxicology, 63, 212-220.


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Kim, M. C., Lee, C. H., & Yook, T. H. (2013). Effects of anti-inflammatory and Rehmanniae radix pharmacopuncture on atopic dermatitis in NC/Nga mice. Journal of acupuncture and meridian studies, 6(2), 98-109.


 9.

Lee, J. N., Lee, C. H., & Kim, Y. S. (2015). Protective effects of Opuntia humifusa cladode extracts against biostir AD-induced atopic dermatitis in NC/Nga mice. Food Science and Biotechnology, 24(3), 1123-1130.


10.

Yu, J. S., Kim, J. U., Lee, C. H., Lee, S. R., & Yook, T. H. (2015). The Effects of Lonicerae Flos, Forsythiae Fluctus and Decoction Pharmacopuncture on Atopic Dermatitis in NC/Nga Mice. The Acupuncture, 32(4), 119-131.


11.

Won, T. J., Kim, B., Lim, Y. T., Song, D. S., Park, S. Y., Park, E. S., … & Hwang, K. W. (2011). Oral administration of Lactobacillus strains from Kimchi inhibits atopic dermatitis in NC/Nga mice. Journal of applied microbiology, 110(5), 1195-1202.


12.

Lee, H., Lee, J. K., Ha, H., Lee, M. Y., Seo, C. S., & Shin, H. K. (2012). Angelicae Dahuricae Radix inhibits dust mite extract-induced atopic dermatitis-like skin lesions in Nc/Nga mice. Evidence-based Complementary and Alternative Medicine, 2012.


13.

Lee, H., Ha, H., Lee, J. K., Seo, C. S., Lee, N. H., Jung, D. Y., … & Shin, H. K. (2012). The fruits of Cudrania tricuspidata suppress development of atopic dermatitis in NC/Nga mice. Phytotherapy Research, 26(4), 594-599.


14.

Takeshita, S., Tokunaga, T., Tanabe, Y., Arinami, T., Ichinose, T., & Noguchi, E. (2015). Asian sand dust aggregate causes atopic dermatitis-like symptoms in Nc/Nga mice. Allergy, Asthma & Clinical Immunology, 11(1), 3.


15.

Negi, O., Tominaga, M., Tengara, S., Kamo, A., Taneda, K., Suga, Y., … & Takamori, K. (2012). Topically applied semaphorin 3A ointment inhibits scratching behavior and improves skin inflammation in NC/Nga mice with atopic dermatitis. Journal of dermatological science, 66(1), 37-43.

 

16.

Yang, G., Choi, C. H., Lee, K., Lee, M., Ham, I., & Choi, H. Y. (2013). Effects of Catalpa ovata stem bark on atopic dermatitis-like skin lesions in NC/Nga mice. Journal of ethnopharmacology, 145(2), 416-423.


17.

Ha, H., Lee, J. K., Lee, M. Y., Lim, H. S., & Shin, H. (2013). Galgeun-tang, an Herbal Formula, Ameliorates Atopic Dermatitis Responses in Dust Mite Extract-treated NC/Nga Mice. Journal of Korean Medicine, 34(4), 1-11.


18.

Won, T. J., Kim, B., Lee, Y., Bang, J. S., Oh, E. S., Yoo, J. S., … & Park, S. Y. (2012). Therapeutic potential of Lactobacillus plantarum CJLP133 for house-dust mite-induced dermatitis in NC/Nga mice. Cellular immunology, 277(1-2), 49-57.


19.

Tanaka, K., Ohgo, Y., Katayanagi, Y., Yasui, K., Hiramoto, S., Ikemoto, H., … & Imai, S. (2014). Anti-inflammatory effects of green soybean extract irradiated with visible light. Scientific reports, 4, 4732.


20.

Karuppagounder, V., Arumugam, S., Thandavarayan, R. A., Pitchaimani, V., Sreedhar, R., Afrin, R., … & Suzuki, K. (2014). Resveratrol attenuates HMGB1 signaling and inflammation in house dust mite-induced atopic dermatitis in mice. International immunopharmacology, 23(2), 617-623.


21.

Matsumoto, M., Ebata, T., Hirooka, J., Hosoya, R., Inoue, N., Itami, S., … & Fujita, A. (2014). Antipruritic effects of the probiotic strain LKM512 in adults with atopic dermatitis. Annals of Allergy, Asthma & Immunology, 113(2), 209-216.


22.

Bae, I. H., Yun, J. W., Seo, J. A., Jung, K. M., Kim, K., Noh, M., … & Lim, K. M. (2010). Immunohistological comparison of cutaneous pathology of three representative murine atopic dermatitis models. Journal of dermatological science, 59(1), 57-60.


23.

Ha, H., Lee, H., Seo, C. S., Lim, H. S., Lee, J. K., Lee, M. Y., & Shin, H. (2014). Artemisia capillaris inhibits atopic dermatitis-like skin lesions in Dermatophagoides farinae-sensitized Nc/Nga mice. BMC complementary and alternative medicine, 14(1), 100.


24.

Eto, H., Tsuji, G., Chiba, T., Furue, M., & Hyodo, F. (2017). Non-invasive evaluation of atopic dermatitis based on redox status using in vivo dynamic nuclear polarization magnetic resonance imaging. Free Radical Biology and Medicine, 103, 209-215.


25.

Yun, J. W., Seo, J. A., Jeong, Y. S., Bae, I. H., Jang, W. H., Lee, J., … & Lim, K. M. (2011). TRPV1 antagonist can suppress the atopic dermatitis-like symptoms by accelerating skin barrier recovery. Journal of dermatological science, 62(1), 8-15.


26.

Kawahara, T., Tsutsui, K., Nakanishi, E., Inoue, T., & Hamauzu, Y. (2017). Effect of the topical application of an ethanol extract of quince seeds on the development of atopic dermatitis-like symptoms in NC/Nga mice. BMC complementary and alternative medicine, 17(1), 80.

27.

Kim, M. S., Kim, J. E., Yoon, Y. S., Kim, T. H., Seo, J. G., Chung, M. J., & Yum, D. Y. (2015). Improvement of atopic dermatitis-like skin lesions by IL-4 inhibition of P14 protein isolated from Lactobacillus casei in NC/Nga mice. Applied microbiology and biotechnology, 99(17), 7089-7099.


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Komatsu, K. I., Takanari, J., Maeda, T., Kitadate, K., Sato, T., Mihara, Y., … & Wakame, K. (2016). Perilla leaf extract prevents atopic dermatitis induced by an extract of Dermatophagoides farinae in NC/Nga mice. Asian Pac. J. Allergy Immunol., 34, 272-277.


29.

Sung, Y. Y., Lee, A. Y., & Kim, H. K. (2014). The Gardenia jasminoides extract and its constituent, geniposide, elicit anti-allergic effects on atopic dermatitis by inhibiting histamine in vitro and in vivo. Journal of ethnopharmacology, 156, 33-40.


30.

Wakame, K., Komatsu, K. I., Inagawa, H., & Nishizawa, T. (2015). Immunopotentiator from Pantoea agglomerans prevents atopic dermatitis induced by Dermatophagoides farinae extract in NC/Nga mouse. Anticancer research, 35(8), 4501-4508.


31.

Ha, H., Lim, H. S., Lee, M. Y., Shin, I. S., Jeon, W. Y., Kim, J. H., & Shin, H. K. (2015). Luffa cylindrica suppresses development of Dermatophagoides farinae-induced atopic dermatitis-like skin lesions in Nc/Nga mice. Pharmaceutical biology, 53(4), 555-562.


32.

Fukuyama, T., Tajima, Y., Hayashi, K., Ueda, H., & Kosaka, T. (2011). Prior or coinstantaneous oral exposure to environmental immunosuppressive agents aggravates mite allergen-induced atopic dermatitis-like immunoreaction in NC/Nga mice. Toxicology, 289(2-3), 132-140.


33.

Ignacio, R. M. C., Kwak, H. S., Yun, Y. U., Sajo, M., Yoon, Y. S., Kim, C. S., … & Lee, K. J. (2013). The drinking effect of hydrogen water on atopic dermatitis induced by Dermatophagoides farinae allergen in NC/Nga mice. Evidence-Based Complementary and Alternative Medicine, 2013.


34.

Kumar, P., Hosain, M. Z., Kang, J. H., Takeo, M., Kishimura, A., Mori, T., & Katayama, Y. (2015). Suppression of atopic dermatitis in mice model by reducing inflammation utilizing phosphatidylserine-coated biodegradable microparticles. Journal of Biomaterials Science, Polymer Edition, 26(18), 1465-1474.


35.

Karuppagounder, V., Arumugam, S., Thandavarayan, R. A., Pitchaimani, V., Sreedhar, R., Afrin, R., … & Suzuki, K. (2015). Modulation of HMGB 1 translocation and RAGE/NF κB cascade by quercetin treatment mitigates atopic dermatitis in NC/Nga transgenic mice. Experimental dermatology, 24(6), 418-423.


36.

Sung, Y. Y., Kim, D. S., Yang, W. K., Nho, K. J., Seo, H. S., Kim, Y. S., & Kim, H. K. (2012). Inhibitory effects of Drynaria fortunei extract on house dust mite antigen-induced atopic dermatitis in NC/Nga mice. Journal of ethnopharmacology, 144(1), 94-100.


37.

Kawasaki, H., Tominaga, M., Shigenaga, A., Kamo, A., Kamata, Y., Iizumi, K., … & Yamakura, F. (2014). Importance of tryptophan nitration of carbonic anhydrase III for the morbidity of atopic dermatitis. Free Radical Biology and Medicine, 73, 75-83.


38.

Katayanagi, Y., Yasui, K., Ikemoto, H., Taguchi, K., Fukutomi, R., Isemura, M., … & Imai, S. (2013). The clinical and immunomodulatory effects of green soybean extracts. Food chemistry, 138(4), 2300-2305.


39.

Sung, Y. Y., Yoon, T., Jang, J. Y., Park, S. J., & Kim, H. K. (2011). Topical application of Rehmannia glutinosa extract inhibits mite allergen-induced atopic dermatitis in NC/Nga mice. Journal of Ethnopharmacology, 134(1), 37-44.


40.

Hara, Y., Shoji, J., Hori, S., Ishimori, A., Kato, H., Inada, N., & Sawa, M. (2012). Evaluation of eosinophilic inflammation in a novel murine atopic keratoconjunctivitis model induced by crude Dermatophagoides farinae antigen. Allergology International, 61(2), 331-338.


41.

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42.

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Hwang, Y., Chang, B., Kim, T., & Kim, S. (2019). Ameliorative effects of green tea extract from tannase digests on house dust mite antigen-induced atopic dermatitis-like lesions in NC/Nga mice. Archives of dermatological research, 311(2), 109-120.


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Biostir®特应性皮炎诱导剂AD
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Biostir®特应性皮炎诱导剂AD
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