标签归档：interphotoreceptor

Interphotoreceptor retinoid-binding protein(668-687)(Synonyms: IRBP(668-687))

发表于由

Interphotoreceptor retinoid-binding protein(668-687);(Synonyms: IRBP(668-687))

Interphotoreceptor retinoid-binding protein(668-687) 是光受体视黄醇类结合蛋白的 668 到 687 氨基酸序列，可诱发葡萄膜炎。

Interphotoreceptor retinoid-binding protein(668-687)amp;;(Synonyms: IRBP(668-687))

Interphotoreceptor retinoid-binding protein(668-687) Chemical Structure

CAS No. : 1977546-93-2

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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生物活性

Interphotoreceptor retinoid-binding protein(668-687), the amino acid residues 668 to 687 of human interphotoreceptor retinoid binding protein (IRBP), induces uveitis[1].

分子量

2107.32

Formula

C91H151N25O32
CAS 号

1977546-93-2
Sequence Shortening

LAQGAYRTAVDLESLASQLT
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Mattapallil MJ, et al. Characterization of a New Epitope of IRBP That Induces Moderate to Severe Uveoretinitis in Mice With H-2b Haplotype. Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5439-49.

Interphotoreceptor Retinoid Binding Protein Fragment (IRBP)

发表于由

Interphotoreceptor Retinoid Binding Protein Fragment (IRBP);

Interphotoreceptor Retinoid Binding Protein Fragment (IRBP)，具有 20 个残基肽，也是主要的致病表位，存在于光受体间类视黄醇结合蛋白肽 (IRBP 161-180) 的第一个同源重复中, 可引起后葡萄膜炎 (EAU)。

Interphotoreceptor Retinoid Binding Protein Fragment (IRBP)amp;;

Interphotoreceptor Retinoid Binding Protein Fragment (IRBP) Chemical Structure

CAS No. : 211426-18-5

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Interphotoreceptor Retinoid Binding Protein Fragment (IRBP), a 20-residue peptide and a major pathogenic epitope, is present in the first homologous repeat of the interphotoreceptor retinoid binding protein peptide (IRBP 161–180), which can induce posterior uveitis (EAU)[1].

分子量

2209.50

Formula

C103H157N25O29
CAS 号

211426-18-5
Sequence

Ser-Gly-Ile-Pro-Tyr-Ile-Ile-Ser-Tyr-Leu-His-Pro-Gly-Asn-Thr-Ile-Leu-His-Val-Asp
Sequence Shortening

SGIPYIISYLHPGNTILHVD
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tang J, et al. Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signatureand is driven by unique effector mechanisms: initial encounter with autoantigen defines diseasephenotype. J Immunol. 2007 May 1;178(9):5578-87.

    [2]. Cortes LM, et al. Inhibitory peptide analogs derived from a major uveitogenic epitope protect from antiretinalautoimmunity by inducing type 2 and regulatory T cells. J Leukoc Biol. 2008 Aug;84(2):577-85.

    [3]. Yang H, et al. Activation of liver X receptor alleviates ocular inflammation in experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 2014 Apr 28;55(4):2795-804.