标签归档：irbp

IRBP (1-20), human TFA

发表于由

IRBP (1-20), human TFA; 纯度: 99.63%

IRBP (1-20), human TFA 包含 H-2b 单倍型的主要表位。IRBP (1-20), human TFA 诱导H-2b 小鼠实验性自身免疫性葡萄膜视网膜炎 (EAU)。

IRBP (1-20), human TFAamp;;

IRBP (1-20), human TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ￥1800 In-stock
5 mg ￥4800 In-stock
10 mg ￥8000 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

IRBP (1-20), human TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

IRBP (1-20), human TFA contains a major epitope for the H-2b haplotype. IRBP (1-20), human TFA induces experimental autoimmune uveoretinitis (EAU) in H-2b mice[1][2].

体内研究
(In Vivo)

IRBP (1-20), human TFA induces EAU[2].
For determination of proliferative and cytokine responses, lymph node and spleen cells are collected 21 days after immunization and are stimulated in culture with the appropriate antigen. Cells of C57BL/6 mice and 129/J mice immunized with IRBP (1-20), human TFA proliferated in response to the peptide[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (H-2b) mice, H-2b (C57BL/6, 129/J) mice[2]
Dosage: 200, 300 μg
Administration: I.h.; After 21 days
Result: C57BL/6 (H-2b) mice immunized with the human peptide (200-300 μg= 80-120 nmoles) developed EAU. 129/J mice (H-2b) also developed disease, albeit with a lower average score than C57BL/6.

分子量

2308.62

Formula

C103H165F3N24O30S
Sequence

Gly-Pro-Thr-His-Leu-Phe-Gln-Pro-Ser-Leu-Val-Leu-Asp-Met-Ala-Lys-Val-Leu-Leu-Asp
Sequence Shortening

GPTHLFQPSLVLDMAKVLLD
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
参考文献

  • [1]. Avichezer D, et al. Residues 1-20 of IRBP and whole IRBP elicit different uveitogenic and immunological responses in interferon gamma deficient mice. Exp Eye Res. 2000;71(2):111‐118.

    [2]. Avichezer D, Silver PB, Chan CC, Wiggert B, Caspi RR. Identification of a new epitope of human IRBP that induces autoimmune uveoretinitis in mice of the H-2b haplotype. Invest Ophthalmol Vis Sci. 2000;41(1):127‐131.

Interphotoreceptor Retinoid Binding Protein Fragment (IRBP)

发表于由

Interphotoreceptor Retinoid Binding Protein Fragment (IRBP);

Interphotoreceptor Retinoid Binding Protein Fragment (IRBP)，具有 20 个残基肽，也是主要的致病表位，存在于光受体间类视黄醇结合蛋白肽 (IRBP 161-180) 的第一个同源重复中, 可引起后葡萄膜炎 (EAU)。

Interphotoreceptor Retinoid Binding Protein Fragment (IRBP)amp;;

Interphotoreceptor Retinoid Binding Protein Fragment (IRBP) Chemical Structure

CAS No. : 211426-18-5

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Interphotoreceptor Retinoid Binding Protein Fragment (IRBP), a 20-residue peptide and a major pathogenic epitope, is present in the first homologous repeat of the interphotoreceptor retinoid binding protein peptide (IRBP 161–180), which can induce posterior uveitis (EAU)[1].

分子量

2209.50

Formula

C103H157N25O29
CAS 号

211426-18-5
Sequence

Ser-Gly-Ile-Pro-Tyr-Ile-Ile-Ser-Tyr-Leu-His-Pro-Gly-Asn-Thr-Ile-Leu-His-Val-Asp
Sequence Shortening

SGIPYIISYLHPGNTILHVD
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tang J, et al. Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signatureand is driven by unique effector mechanisms: initial encounter with autoantigen defines diseasephenotype. J Immunol. 2007 May 1;178(9):5578-87.

    [2]. Cortes LM, et al. Inhibitory peptide analogs derived from a major uveitogenic epitope protect from antiretinalautoimmunity by inducing type 2 and regulatory T cells. J Leukoc Biol. 2008 Aug;84(2):577-85.

    [3]. Yang H, et al. Activation of liver X receptor alleviates ocular inflammation in experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 2014 Apr 28;55(4):2795-804.