H-Ile-Pro-Pro-OH

H-Ile-Pro-Pro-OH;

H-Ile-Pro-Pro-OH 是一种乳源三肽，抑制血管紧张素转换酶 (ACE) ，IC₅₀ 为 5 μM。具有抗高血压效果。

H-Ile-Pro-Pro-OH Chemical Structure

CAS No. : 26001-32-1

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H-Ile-Pro-Pro-OH 的其他形式现货产品:

H-Ile-Pro-Pro-OH hydrochloride

生物活性	H-Ile-Pro-Pro-OH, a milk-derived peptide^[1], inhibits angiotensin-converting enzyme (ACE)^[1] with an IC₅₀ of 5 μM^[2]. Antihypertensive tripeptides^[1].
IC₅₀ Target	IC50: 5 μM (ACE)^[2]
体外研究 (In Vitro)	Ile-Pro-Pro (IPP; 1 nM, 0.1 μM, and 10 μM) increases nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs)^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)	Ile-Pro-Pro (IPP; 30 mg/kg per day; 0.3 g/L) attenuates arterial dysfunction in L-NAME-treated rats^[1] Ile-Pro-Pro decreases blood pressure in spontaneously hypertensive rats (SHR) ^[1]. Ile-Pro-Pro attenuates the development of atherosclerosis in apolipoprotein E-deficient (apoE(-/-)) mice^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	325.40
Formula	C₁₆H₂₇N₃O₄
CAS 号	26001-32-1
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Nonaka A, et al. The milk-derived peptides Val-Pro-Pro and Ile-Pro-Pro attenuate arterial dysfunction in L-NAME-treated rats. Hypertens Res. 2014 Aug;37(8):703-7. [2]. Nakamura Y, et al. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci. 1995 Apr;78(4):777-83.

H-Val-Pro-Pro-OH

H-Val-Pro-Pro-OH;

H-Val-Pro-Pro-OH，是牛奶来源的脯氨酸肽衍生物，是血管紧张素 I 转化酶 (ACE) 的抑制剂，其IC₅₀ 为 9 μM。

H-Val-Pro-Pro-OH Chemical Structure

CAS No. : 58872-39-2

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H-Val-Pro-Pro-OH 的其他形式现货产品:

H-Val-Pro-Pro-OH TFA

生物活性	H-Val-Pro-Pro-OH, a milk-derived proline peptides derivative, is an inhibitor of Angiotensin I converting enzyme (ACE), with an IC₅₀ of 9 μM.
IC₅₀ Target	IC50: 9 μM (ACE)^[1].
体外研究 (In Vitro)	H-Val-Pro-Pro-OH, a proline peptides derivative, could inhibit Angiotensin I converting enzyme (ACE), with an IC₅₀ of 9 μM^[1]. H-Val-Pro-Pro-OH could enhance insulin sensitivity and prevent insulin resistance in 3T3-F442A pre-adipocytes. H-Val-Pro-Pro-OH also has anti-hypertensive and anti-inflammatory functions. H-Val-Pro-Pro-OH further enhances the expression of glucose transporter 4 (GLUT4) in adipocytes and restores glucose uptake in TNF-treated adipocytes^[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	311.38
Formula	C₁₅H₂₅N₃O₄
CAS 号	58872-39-2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Nakamura Y, et al. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci. 1995 Apr;78(4):777-83. [2]. Chakrabarti S, et al. Milk-Derived Tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) Enhance Insulin Sensitivity and Prevent Insulin Resistance in 3T3-F442A Preadipocytes. J Agric Food Chem. 2018 Oct 3;66(39):10179-10187.