标签归档：deoxysappanchalcone

3-Deoxysappanchalcone

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天然产物 黄酮类 Flavonoids

3-Deoxysappanchalcone 

3-Deoxysappanchalcone 是一种从豆科植物 Caesalpinia sappan L. 中分离得到的天然查尔酮化合物，具有抗过敏、抗病毒、抗炎和抗氧化活性。3-Deoxysappanchalcone 通过激活小鼠巨噬细胞中 AKT/mTOR 通路诱导血红素加氧酶 -1 (HO-1) 的表达，发挥抗炎作用。3-Deoxysappanchalcone 具有抗流感病毒活性 (H3N2, IC50 = 1.06 μM)。

3-Deoxysappanchalcone

3-Deoxysappanchalcone Chemical Structure

CAS No. : 112408-67-0

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生物活性

3-Deoxysappanchalcone is a naturally-occurring chalcone compound isolated from Caesalpinia sappan L. (Leguminosae), which possesses anti-allergic, antiviral, anti-inflammatory and antioxidant activities. 3-Deoxysappanchalcone exerts anti-inflammatory activity via induce heme oxygenase-1 (HO-1) expression by activating the AKT/mTOR pathway in murine macrophages. 3-Deoxysappanchalcone also exhibits anti-influenza virus activity (H3N2, IC50 = 1.06 μM)[1][2].

IC50 & Target

IC50: 1.06 μM (H3N2)[2]
分子量

270.28

Formula

C16H14O4
CAS 号

112408-67-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kim JH, et al. The anti-inflammatory effect of 3-deoxysappanchalcone is mediated by inducing heme oxygenase-1 via activating the AKT/mTOR pathway in murine macrophages. Int Immunopharmacol. 2014 Oct;22(2):420-6.

    [2]. Liu AL, et al. In vitro anti-influenza viral activities of constituents from Caesalpinia sappan. Planta Med. 2009 Mar;75(4):337-9.