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Pseudolaric Acid B(Synonyms: 土荆皮乙酸) 纯度: ≥98.0%
Pseudolaric Acid B 是一种从 Pseudolarix kaempferi Gorden (pinaceae) 根部分离的二萜酸,具有抗癌、抗真菌、抗受精活性,并对 T 淋巴细胞也具有免疫抑制活性。Pseudolaric Acid B 通过凋亡和细胞周期阻滞抑制乙肝病毒 (HBV) 的分泌。Pseudolaric Acid B 诱导细胞自噬。
Pseudolaric Acid B Chemical Structure
CAS No. : 82508-31-4
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生物活性
Pseudolaric Acid B is a diterpene isolated from the root of Pseudolarix kaempferi Gorden (pinaceae), has anti-cancer, antifungal, and antifertile activities, and shows immunosuppressive activity on T lymphocytes[1][2][3]. Pseudolaric Acid B inhibits hepatitis B virus (HBV) secretion through apoptosis and cell cycle arrest. Pseudolaric Acid B induces autophagy[4][5].
分子量
432.46
Formula
C23H28O8
CAS 号
82508-31-4
中文名称
土荆皮乙酸
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Zhou BN, et al. Some progress on the chemistry of natural bioactive terpenoids from Chinese medicinal plants. Mem Inst Oswaldo Cruz. 1991;86 Suppl 2:219-26.
[2]. Wang WC, et al. [Endocrine activity of pseudolaric acids A and B and their effects on sex hormones, prostaglandins, uteri, and fetuses]. Zhongguo Yao Li Xue Bao. 1991 Mar;12(2):187-90.
[3]. Wei N, et al. The immunosuppressive activity of pseudolaric acid B on T lymphocytes in vitro. Phytother Res. 2013 Jul;27(7):980-5.
[4]. Yu J, et al. Pseudolaric acid B inhibits the secretion of hepatitis B virus. Oncol Rep. 2017 Jan;37(1):519-525.
[5]. Yu J, et al. Pseudolaric acid B activates autophagy in MCF-7 human breast cancer cells to prevent cell death. Oncol Lett. 2016 Mar;11(3):1731-1737.