GsMTx4 TFA

GsMTx4 TFA; 纯度: 98.29%

GsMTx4 TFA 是一种蜘蛛毒液肽,选择性地抑制属于 Piezo 和 TRP 通道家族的阳离子可渗透的机械敏感性通道 (MSCs)。GsMTx4 TFA 是一种重要的药理学工具,用于鉴定兴奋性 MSCs 在正常生理学和病理学中的作用。GsMTx4 TFA 显着减弱膀胱机能亢进。

GsMTx4 TFAamp;;

GsMTx4 TFA Chemical Structure

规格 价格 是否有货 数量
500 μg ¥2700 In-stock
1 mg ¥5000 In-stock
5 mg ¥18000 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

* Please select Quantity before adding items.

GsMTx4 TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

GsMTx4 TFA is a spider venom peptide that selectively inhibits cation-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 TFA is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology[1]. GsMTx4 TFA significantly attenuates bladder hyperactivity[2].

IC50 Target

MSCs[1]

分子量

4215.91

Formula

C187H280N49F3O47S6

Sequence Shortening

GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro:;

DMSO : 10 mg/mL (2.37 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (ultrasonic) (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.2372 mL 1.1860 mL 2.3720 mL
5 mM
10 mM

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Gnanasambandam R, et al. GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels. Biophys J. 2017 Jan 10;112(1):31-45.

    [2]. Liu Q, et al. Increased Piezo1 channel activity in interstitial Cajal-like cells induces bladder hyperactivity by functionally interacting with NCX1 in rats with cyclophosphamide-induced cystitis. Exp Mol Med. 2018 May 7;50(5):60.

D-GsMTx-4 品牌:Peptide


D-GsMTx-4

品牌:Peptide
CAS No.:873785-93-4
储存条件:-20°C
纯度:
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

336-45251

0.1mg 咨询


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动,恕不另行通知,确切详情请联系上海金畔生物科技有限公司。

GsMTx-4 蜘蛛毒素GsMTx-4 品牌:Peptide


GsMTx-4

蜘蛛毒素GsMTx-4

品牌:Peptide
CAS No.:
储存条件:-20℃
纯度:
产品编号

(生产商编号)

等级 规格 运输包装 零售价(RMB) 库存情况 参考值

336-43931

0.1mg 咨询


* 干冰运输、大包装及大批量的产品需酌情添加运输费用


* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动,恕不另行通知,确切详情请联系上海金畔生物科技有限公司。

GsMTx4

GsMTx4;

GsMTx4 是一种蜘蛛毒液肽,选择性地抑制属于 Piezo 和 TRP 通道家族的阳离子可渗透的机械敏感性通道(MSCs)。GsMTx4 是一种重要的药理学工具,用于鉴定兴奋性 MSCs 在正常生理学和病理学中的作用。GsMTx4 显着减弱膀胱机能亢进。

GsMTx4amp;;

GsMTx4 Chemical Structure

CAS No. : 1209500-46-8

规格 价格 是否有货
500 μg ¥2700 询问价格 货期
1 mg ¥5000 询问价格 货期
5 mg ¥18000 询问价格 货期

* Please select Quantity before adding items.

GsMTx4 的其他形式现货产品:

GsMTx4 TFA

生物活性

GsMTx4 is a spider venom peptide that selectively inhibits cation-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology[1]. GsMTx4 significantly attenuates bladder hyperactivity[2].

IC50 Target

MSCs[1]

分子量

4101.89

Formula

C185H279N49O45S6

CAS 号

1209500-46-8

Sequence Shortening

GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Gnanasambandam R, et al. GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels. Biophys J. 2017 Jan 10;112(1):31-45.

    [2]. Liu Q, et al. Increased Piezo1 channel activity in interstitial Cajal-like cells induces bladder hyperactivity by functionally interacting with NCX1 in rats with cyclophosphamide-induced cystitis. Exp Mol Med. 2018 May 7;50(5):60.