PACAP (1-38), human, ovine, rat TFA(Synonyms: Pituitary Adenylate Cyclase Activating Polypeptide 38 TFA)

发表于2023年11月23日由Whatman官网

PACAP (1-38), human, ovine, rat TFA;(Synonyms: Pituitary Adenylate Cyclase Activating Polypeptide 38 TFA)

PACAP (1-38), human, ovine, rat TFA 是一种含有 38 个氨基酸残基的神经肽。PACAP (1-38) 结合到 PACAP I 型受体，PACAP II 型受体 VIP₁ 和 PACAP II 型受体 VIP₂，IC₅₀ 分别为 4 nM，2 nM 和 1 nM。

PACAP (1-38), human, ovine, rat TFAamp;;(Synonyms: Pituitary Adenylate Cyclase Activating Polypeptide 38 TFA)

PACAP (1-38), human, ovine, rat TFA Chemical Structure

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

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PACAP (1-38), human, ovine, rat TFA 的其他形式现货产品:

PACAP (1-38), human, ovine, rat

生物活性

PACAP (1-38), human, ovine, rat TFA is a neuropeptide with 38 amino acid residues. PACAP (1-38) binds to PACAP type I receptor, PACAP type II receptor VIP₁, and PACAP type II receptor VIP₂ with IC₅₀s of 4 nM, 2 nM, and 1 nM, respectively.

IC₅₀ Target

IC50: 4 nM (PACAP type I receptor), 2 nM (PACAP type II receptor VIP₁), and 1 nM (PACAP type II receptor VIP₂)^[1]

分子量

4648.28

Formula

C₂₀₃H₃₃₁N₆₃O₅₃S.C₂HF₃O₂

Sequence

His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2

Sequence Shortening

HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent Solubility

In Vitro:;

H₂O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

;	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3.;;Recommended solution:

Overall charge of peptide	Details
Negative (lt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, add NH₄OH (lt;50 μL). 3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0)	1.;;Try to dissolve the peptide in water first. 2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

参考文献

[1]. Gourlet P, et al. Fragments of pituitary adenylate cyclase activating polypeptide discriminate between type I and II recombinant receptors. Eur J Pharmacol. 1995 Dec 4;287(1):7-11.

PACAP-38 (16-38), human, mouse, rat

发表于2023年10月30日由Whatman官网

PACAP-38 (16-38), human, mouse, rat;

PACAP-38 (16-38), human, mouse, rat对交感神经NPY和儿茶酚胺的产生具有强效、持续的刺激作用。PACAP 是cAMP生成的有效激动剂。

PACAP-38 (16-38), human, mouse, rat Chemical Structure

CAS No. : 144025-82-1

规格		是否有货
100 mg	;	询价	;
250 mg	;	询价	;
500 mg	;	询价	;

* Please select Quantity before adding items.

生物活性

PACAP-38 (16-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production^[1]. PACAP is a potent activator of cAMP formation^[2].

分子量

2720.33

Formula

C₁₂₃H₂₁₅N₃₉O₂₈S

CAS 号

144025-82-1