[1]. Kim HL, et al. Platycodin D, a novel activator of AMP-activated protein kinase, attenuates obesity in db/db mice via regulation of adipogenesis and thermogenesis. Phytomedicine. 2019 Jan;52:254-263.
[1]. Oztürk N, et al. Effects of gentiopicroside, sweroside and swertiamarine, secoiridoids from gentian (Gentiana lutea ssp. symphyandra), on cultured chicken embryonic fibroblasts. Planta Med. 2006 Mar;72(4):289-94.
[2]. Jeong YT, et al. Modulation effects of sweroside isolated from the Lonicera japonica on melanin synthesis. Chem Biol Interact. 2015 Aug 5;238:33-9.
DTE (Dithioerythritol) is a sulfur containing sugar derived from the corresponding 4-carbon monosaccharide erythrose; is an epimer of dithiothreitol(DTT).
分子量
154.25
Formula
C4H10O2S2
CAS 号
6892-68-8
运输条件
Room temperature in continental US; may vary elsewhere.
Praeruptorin B is an inhibitor of sterol regulatory element-binding proteins (SREBPs).
IC50 & Target
SREBP[1].
体外研究 (In Vitro)
Praeruptorin B inhibits the SREBPs activity and decreases intracellular lipid levels. Praeruptorin B is found to powerfully decrease the SRE-luciferase activity, and this effect is dose dependent. Praeruptorin B shows negligible cytotoxicity, even at the higher concentration. Praeruptorin B also significantlytly down-regulates the expression of SREBP-1c and SREBP-2[1]. Praeruptorin B also exhibits significant inhibition on the activity of UGT1A9[2].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)
The mice treated with Praeruptorin B (50 mg/kg) are significantly lighter than the vehicle treated mice, although they are still heavier than the chow diet-fed mice, suggesting that Praeruptorin B can ameliorate diet-induced obesity (DIO). More importantly, the fat/lean and fat/body-weight ratios are obviously dropped at the same dosage of Praeruptorin B treated mice. It is also showed that the serum TC and TG levels of Praeruptorin B treated mice are significantly lower than those of the HFD-fed mice. Praeruptorin B increases HDL-c and decreases LDL-c similar as lovastatin. In addition, compared with vehicle treated mice, Praeruptorin B significantly lowers the level of TC and TG in liver, comparable to lovastatin. The staining results reveal that Praeruptorin B-treated mice exhibit less lipid accumulation than that of vehicle treated mice. The elevated fasting blood glucose and insulin in HFD-fed mice are significantly reduced by Praeruptorin B[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量
426.46
Formula
C24H26O7
CAS 号
73069-28-0
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder
-20°C
3 years
4°C
2 years
In solvent
-80°C
6 months
-20°C
1 month
溶解性数据
In Vitro:
DMSO : 25 mg/mL (58.62 mM; ultrasonic and warming and heat to 60°C)
[1]. Zu-Guo Zheng, et al. Praeruptorin B improves diet-induced hyperlipidemia and alleviates insulin resistance via regulating SREBP signaling pathway. RSC Adv., 2018, 8, 354–366
[2]. Liu X, et al. The Inhibition of UDP-Glucuronosyltransferase (UGT) Isoforms by Praeruptorin A and B. Phytother Res. 2016 Nov;30(11):1872-1878.
Cell Assay [1]
HepG2 cells and HL-7702 cells are used in the study. Cell proliferation is determined by the MTT assays. The HepG2 cells are seeded in 96-well plates with 2.0×104 cells per well in DMEM containing 10% FBS for 24 h. Cells are further treated with Praeruptorin B (0, 2.5, 5, 10, 20, 40, 80 μM) for 18 h[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration [1]
Mice[1] Sixweek-old male C57BL/6J mice are housed in colony cages and maintained on a light/dark cycle. On a caloric basis, the HFD contains 60% fat, 20.6% carbohydrate and 19.4% protein, whereas the normal diet contains 13% fat, 60% carbohydrate and 27% protein. The mice are randomly divided into the following four groups (n=6 per group): vehicle-treated chow group, vehicle-treated HFD group, lovastatin-treated HFD group (30 mg per kg per day) and Praeruptorin B-treated HFD group (25 or 50 mg per kg per day). HFD-fed mice are gavaged with Praeruptorin B or lovastatin dissolved in 0.5% CMC-Na for 6 weeks[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献
[1]. Zu-Guo Zheng, et al. Praeruptorin B improves diet-induced hyperlipidemia and alleviates insulin resistance via regulating SREBP signaling pathway. RSC Adv., 2018, 8, 354–366
[2]. Liu X, et al. The Inhibition of UDP-Glucuronosyltransferase (UGT) Isoforms by Praeruptorin A and B. Phytother Res. 2016 Nov;30(11):1872-1878.
Shionone is the major triterpenoid isolated from Aster tataricus, has anti-tussive, anti-inflammatory activities[1][2]. Shionone possesses a unique six-membered tetracyclic skeleton and 3-oxo-4-monomethyl structure[1].
体内研究 (In Vivo)
Shionone (orally administration; 80 mg/kg; 3 days; once daily) shows the trend of enhancing sputum secreting, but has no effect on ammonia-induced cough and reduces xylene-induced ear edema[1].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:
ICR male mice[1]
Dosage:
80 mg/kg
Administration:
Orally administration; 3 days; once daily
Result:
Reduced the ear edema for 11.3% by use shionone.
分子量
426.72
Formula
C30H50O
CAS 号
10376-48-4
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Sawai S, et al. Molecular characterization of an oxidosqualene cyclase that yields shionone, a unique tetracyclic triterpene ketone of Aster tataricus.FEBS Lett. 2011 Apr 6;585(7):1031-6.
[2]. Yu P, et al. Expectorant, antitussive, anti-inflammatory activities and compositional analysis of Aster tataricus.J Ethnopharmacol. 2015 Apr 22;164:328-33.
Gomisin G is an ethanolic extract of the stems of Kadsura interior; exhibits potent anti-HIV activity with EC50 and therapeutic index (TI) values of 0.006 microgram/mL and 300, respectively.
分子量
536.57
Formula
C30H32O9
CAS 号
62956-48-3
中文名称
戈米辛 G
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Chen DF, et al. Anti-AIDS agents–XXVI. Structure-activity correlations of gomisin-G-related anti-HIV lignans from Kadsura interior and of related synthetic analogues. Bioorg Med Chem. 1997 Aug;5(8):1715-23.
[2]. Ikeya Y, et al. The constituents of Schizandra chinensis Baill. I. Isolation and structure determination of five new lignans, gomisin A, B, C, F and G, and the absolute structure of schizandrin. Chem Pharm Bull (Tokyo). 1979 Jun;27(6):1383-94.
Narirutin, one of the active constituents isolated from Citrus unshiu, has antioxidant and anti-inflammatory activities. Narirutin is a shikimate kinase inhibitor with anti-tubercular potency[1][2].
Clinical Trial
分子量
580.53
Formula
C27H32O14
CAS 号
14259-46-2
中文名称
芸香柚皮苷
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
4°C, sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶解性数据
In Vitro:
DMSO : 125 mg/mL (215.32 mM; Need ultrasonic)
配制储备液
浓度溶剂体积质量
1 mg
5 mg
10 mg
1 mM
1.7226 mL
8.6128 mL
17.2256 mL
5 mM
0.3445 mL
1.7226 mL
3.4451 mL
10 mM
0.1723 mL
0.8613 mL
1.7226 mL
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:
[1]. Sahu PK, et al. Structure-based Discovery of Narirutin as a Shikimate Kinase Inhibitor with Anti-tubercular Potency.Curr Comput Aided Drug Des. 2019 Oct 25.
[2]. Funaguchi N, et al. Narirutin inhibits airway inflammation in an allergic mouse model.Clin Exp Pharmacol Physiol. 2007 Aug;34(8):766-70.
Madecassoside;(Synonyms: 羟基积雪草苷; Asiaticoside A) 纯度: 99.86%
Madecassoside是一个从崩大碗中分离出来的五环三萜,有抗炎症。抗氧化和抗衰老的作用。
Madecassoside Chemical Structure
CAS No. : 34540-22-2
规格
价格
是否有货
数量
10;mM;*;1 mL in DMSO
¥550
In-stock
10 mg
¥500
In-stock
50 mg
¥1500
In-stock
100 mg
¥2400
In-stock
200 mg
¥3900
In-stock
500 mg
;
询价
;
1 g
;
询价
;
* Please select Quantity before adding items.
Madecassoside 相关产品
bull;相关化合物库:
Natural Product Library Plus
Bioactive Compound Library Plus
Apoptosis Compound Library
Metabolism/Protease Compound Library
Natural Product Library
Human Endogenous Metabolite Compound Library
Anti-Aging Compound Library
Glycoside Compound Library
Medicine Food Homology Compound Library
Terpenoids Library
Traditional Chinese Medicine Monomer Library
FDA Approved amp; Pharmacopeial Drug Library
Food-Sourced Compound Library
生物活性
Madecassoside is a pentacyclic triterpene isolated from Centella asitica (L.), as an anti-inflammatory, anti-oxidative activities and anti-aging agent. [1] In vitro: Madecassoside exhibit significant anti-proliferative and anti-invasive effect in HGF-induced HepG2 and SMMC-77 cells. Madecassoside inhibit the HGF-induced activation of cMET-PKC-ERK1/2-COX-2-PGE2cascade. [1] In vivo: Administration of madecassoside, p.o. , exhibit a direct anti-PF effect in mice. Madecassoside increase the expression of hepatocyte growth factor (HGF) in colon tissues, and HGF receptor antagonists attenuated its anti-PF effect. madecassoside in mice are not mediated by its metabolites or itself after absorption into blood. Instead, madecassoside increases the activity of PPAR-γ, which subsequently increases HGF expression in colonic epithelial cells. [2] The reference for administration is 12 mg/kg. [3]
IC50 Target
Human Endogenous Metabolite
;
分子量
975.12
Formula
C48H78O20
CAS 号
34540-22-2
中文名称
羟基积雪草苷;羟基积雪草
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Zexin Li et al. Madecassoside suppresses proliferation and invasiveness of HGF-induced human hepatocellular carcinoma cells via PKC-cMET-ERK1/2-COX-2-PGE2 pathway. Int Immunopharmacol. 2016 Apr;33:24-32.
[2]. Xia Y et al. Madecassoside ameliorates bleomycin-induced pulmonary fibrosis in mice through promoting the generation of hepatocyte growth factor via PPAR-γ in colon. Br J Pharmacol. 2016 Apr;173(7):1219-35
[3]. Su Z et al. Protective effects of madecassoside against Doxorubicin induced nephrotoxicity in vivo and in vitro. Sci Rep. 2015 Dec 14