β-Caryophyllene(Synonyms: β-石竹烯; (-)-(E)-Caryophyllene; (−)-β-caryophyllene; (−)-trans-Caryophyllene)

发表于2024年5月15日由Whatman官网

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

β-Caryophyllene (Synonyms: β-石竹烯; (-)-(E)-Caryophyllene; (−)-β-caryophyllene; (−)-trans-Caryophyllene) 纯度: 98.32%

β-Caryophyllene 是一个 CB2 受体激动剂。

β-Caryophyllene Chemical Structure

CAS No. : 87-44-5

规格	价格	是否有货
500 mg	￥500	In-stock
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5 g		询价

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Terpenoids Library
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Anti-Pancreatic Cancer Compound Library
Food Additive Library
Food-Sourced Compound Library

生物活性

β-Caryophyllene is a CB2 receptor agonist.

IC₅₀ & Target

Human Endogenous Metabolite

体外研究
(In Vitro)

Among the tested cancer cells, β-Caryophyllene demonstrates selective anti-proliferative effect against three cancer cell lines, namely HCT 116 (colon cancer, IC₅₀=19 μM), PANC-1 (pancreatic cancer, IC₅₀=27 μM), and HT29 (colon cancer, IC₅₀=63 μM) cells, whereas β-Caryophyllene exhibits either moderate or poor cytotoxic effects against ME-180, PC3, K562 and MCF-7. Results show that β-Caryophyllene possesses higher selectivity towards the colorectal cancer cells (HCT 116), with selectivity index (SI)=27.9, followed by PANC-1 and HT 29 cells with SI=19.6 and 8, respectively. The apoptotic index estimated for β-Caryophyllene treatment on HCT 116 cells after 24 h treatment is 64±0.04. β-Caryophyllene at 10 μM concentration, causes significant nuclei condensation after 6 h of treatment. β-caryophyllene exhibits a dose and time-dependent inhibitory effect on the motility of HCT 116 cells^[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Treatment with β-Caryophyllene at different doses does not show any effects on swimming speed during the test. Oral treatment with β-Caryophyllene ameliorates the rise in β-amyloid deposition in the transgenic mice in a roughly dose-dependent manner, and the two higher doses exhibit almost equal effects in modifying the β-amyloid burden. The number of activated astroglial cells is higher in vehicle-treated mouse brains than in β-Caryophyllene-treated mouse brains with different doses. β-Caryophyllene is effective at reducing the enhancement of the COX-2 protein level found in vehicle-treated APP/PS1 mice^[1]. Animals treated with β-Caryophyllene display higher values of object recognition index than their vehicle-treated counterparts [t(14)=4.204, P<0.05]. The total time spent in object exploration during the test trial is not significantly different between β-Caryophyllene-treated and vehicle-treated animals (t(14)=0.5874, P>0.05). Treatment with β-Caryophyllene does not significantly alter these seizure-induced neurochemical changes^[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

204.35

Formula

C₁₅H₂₄

CAS 号

87-44-5

中文名称

β-石竹烯；β-丁香烯

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

Ethanol : ≥ 176.67 mg/mL (864.55 mM)

DMSO : 100 mg/mL (489.36 mM; Need ultrasonic)

H₂O : < 0.1 mg/mL (insoluble)

* “≥” means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.8936 mL	24.4678 mL	48.9356 mL
5 mM	0.9787 mL	4.8936 mL	9.7871 mL
10 mM	0.4894 mL	2.4468 mL	4.8936 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% EtOH 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 13.25 mg/mL (64.84 mM); Clear solution

此方案可获得 ≥ 13.25 mg/mL (64.84 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 132.5 mg/mL 的澄清 EtOH 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% EtOH 90% (20% SBE-β-CD in saline)

Solubility: 13.25 mg/mL (64.84 mM); Suspended solution; Need ultrasonic

此方案可获得 13.25 mg/mL (64.84 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

以 1 mL 工作液为例，取 100 μL 132.5 mg/mL 的澄清 EtOH 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% EtOH 90% corn oil

Solubility: ≥ 13.25 mg/mL (64.84 mM); Clear solution

此方案可获得 ≥ 13.25 mg/mL (64.84 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 132.5 mg/mL 的澄清 EtOH 储备液加到 900 μL玉米油中，混合均匀。
4.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (12.23 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (12.23 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
5.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (12.23 mM); Suspended solution; Need ultrasonic

此方案可获得 2.5 mg/mL (12.23 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
6.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (12.23 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (12.23 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。

参考文献

[1]. Cheng Y, et al. β-Caryophyllene ameliorates the Alzheimer-like phenotype in APP/PS1 Mice through CB2 receptor activation and the PPARγ pathway. Pharmacology. 2014;94(1-2):1-12.

[2]. Dahham SS, et al. The Anticancer, Antioxidant and Antimicrobial Properties of the Sesquiterpene β-Caryophyllenefrom the Essential Oil of Aquilaria crassna. Molecules. 2015 Jun 26;20(7):11808-29.

[3]. de Oliveira CC, et al. Anticonvulsant activity of β-caryophyllene against pentylenetetrazol-induced seizures. Epilepsy Behav. 2016 Mar;56:26-31.

Cell Assay ^[2]	Panel of human cancer cells such as, pancreatic (PANC-1), colorectal (HCT-116 and HT-29), invasive squamous cell carcinoma (ME-180), leukemia (K562), hormone sensitive and invasive breast cancer cell line (MCF-7), and prostatic (PC3) adenocarcinoma cell lines are used. Cells are incubated in a humidified CO₂ incubator at 37°C supplied with 5% CO₂. Inhibitory effect of β-Caryophyllene on proliferation of the cell lines is tested using the MTT assay. The selectivity index (SI) for the cytotoxicity of β-Caryophyllene is calculated using the ratio of IC₅₀ of β-Caryophyllene on a normal cell line (NIH-3T3) to the IC₅₀ of β-Caryophyllene on cancer cell lines^[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration ^[1]	Male double transgenic APP/PS1 mice and wild-type littermates are used. The mice are group housed (3 to 5 animals/cage) with a 12:12-hour light/dark cycle and ad libitum access to food and water. In this experiment, animals are orally treated by gavage with 16, 48, or 144 mg/kg of β-Caryophyllene every morning for 10 weeks starting at the age of 7 months. All vehicle solutions are used for the respective control animal treatments and the Morris water maze test is performed^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Cheng Y, et al. β-Caryophyllene ameliorates the Alzheimer-like phenotype in APP/PS1 Mice through CB2 receptor activation and the PPARγ pathway. Pharmacology. 2014;94(1-2):1-12. [2]. Dahham SS, et al. The Anticancer, Antioxidant and Antimicrobial Properties of the Sesquiterpene β-Caryophyllenefrom the Essential Oil of Aquilaria crassna. Molecules. 2015 Jun 26;20(7):11808-29. [3]. de Oliveira CC, et al. Anticonvulsant activity of β-caryophyllene against pentylenetetrazol-induced seizures. Epilepsy Behav. 2016 Mar;56:26-31.

trans-Cinnamic acid(Synonyms: 反式肉桂酸; trans-3-Phenylacrylic acid)

发表于2024年5月3日由Whatman官网

天然产物天然产物苯丙素类 Phenylpropanoids

trans-Cinnamic acid (Synonyms: 反式肉桂酸; trans-3-Phenylacrylic acid) 纯度: 99.98%

trans-Cinnamic acid 是一种杀菌剂，对鱼的病原菌温和气单胞菌 (A. sobria, SY-AS1) 的最低抑制浓度 (MIC) 为 250 μg/mL。

trans-Cinnamic acid Chemical Structure

CAS No. : 140-10-3

规格	价格	是否有货
Free Sample (0.1-0.5 mg)		Apply now
10 mM * 1 mL in DMSO	￥550	In-stock
100 mg	￥500	In-stock
200 mg		询价
500 mg		询价

* Please select Quantity before adding items.

trans-Cinnamic acid 相关产品

•相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Anti-Infection Compound Library
Metabolism/Protease Compound Library
Natural Product Library
Anti-Cancer Compound Library
Human Endogenous Metabolite Compound Library
Fragment Library
Antibacterial Compound Library
Traditional Chinese Medicine Monomer Library
FDA Approved & Pharmacopeial Drug Library
Gut Microbial Metabolite Library
Microbial Metabolite Library
Food-Sourced Compound Library

生物活性

trans-Cinnamic acid is a natural antimicrobial, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1^[1].

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

体外研究
(In Vitro)

trans-Cinnamic acid is an antimicrobial activity, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1. trans-cinnamic acid shows moderate inhibition on the rainbow trout intestinal isolates A. sobria SY-AS3 and S. baltica, SY-S145, gill isolate F. spartansii SY-FS1 and fish pathogens A. salmonicida ATCC 33658, Listonella anguillarum, SY-L24, V. crassostreae SY-VC10 and Y. ruckeri E42. trans-cinnamic acid is more effective on bacteria when the pH of the culture media is not neutralized^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

148.16

Formula

C₉H₈O₂

CAS 号

140-10-3

中文名称

反式肉桂酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL (674.95 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	6.7495 mL	33.7473 mL	67.4946 mL
5 mM	1.3499 mL	6.7495 mL	13.4989 mL
10 mM	0.6749 mL	3.3747 mL	6.7495 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (16.87 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (16.87 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (16.87 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (16.87 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (16.87 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (16.87 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Yilmaz S, et al. Antimicrobial activity of trans-cinnamic acid and commonly used antibiotics against important fish pathogens and nonpathogenic isolates. J Appl Microbiol. 2018 Sep 4.

trans-1,2-Cyclohexanediaminetetraacetic acid

发表于2024年5月2日由Whatman官网

生化分析试剂 Biochemical Assay Reagents
trans-1,2-Cyclohexanediaminetetraacetic acid; 纯度: ge;97.0%

trans-1,2-Cyclohexanediaminetetraacetic acid 是一种常用的氨基多羧酸，是一种强的重金属离子螯合剂。

trans-1,2-Cyclohexanediaminetetraacetic acid Chemical Structure

CAS No. : 13291-61-7

规格	价格	是否有货	数量
500 mg	￥500	In-stock
1 g	;	询价	;
5 g	;	询价	;

* Please select Quantity before adding items.

trans-1,2-Cyclohexanediaminetetraacetic acid 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus

生物活性

trans-1,2-Cyclohexanediaminetetraacetic acid is a commonly used aminopolycarboxylic acid and a strong chelator of heavy metal ions^[1]^[2].

分子量

346.33

Formula

C₁₄H₂₂N₂O₈

CAS 号

13291-61-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20deg;C	3 years
	4deg;C	2 years
In solvent	-80deg;C	6 months
	-20deg;C	1 month

溶解性数据

In Vitro:;

H₂O : < 0.1 mg/mL (ultrasonic;warming;heat to 80°C) (insoluble)

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

Solubility: ≥ 1.67 mg/mL (4.82 mM); Clear solution

此方案可获得 ≥ 1.67 mg/mL (4.82 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 16.7 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Wen Chen, et al. Uranium(VI) complexation withtrans-1,2-cyclohexanediaminetetraacetic acid in solution: thermodynamic and structural studies,Journal of Coordination Chemistry.

[2]. Zhang T, et al. Chelant extraction of heavy metals from contaminated soils using new selective EDTA derivatives. J Hazard Mater. 2013;262:464-471.

Trans-Anethole(Synonyms: (E)-Anethole)

发表于2024年4月28日由Whatman官网

天然产物天然产物苯丙素类 Phenylpropanoids

Trans-Anethole (Synonyms: (E)-Anethole) 纯度: 99.70%

Trans-Anethole ((E)-Anethole) 是从 Pimpinella 分离得到的一种苯丙烯衍生物，在肿瘤细胞系中，低浓度下有雌激素活性，而在高浓度下具有细胞毒性。Trans-Anethole ((E)-Anethole) 是茴香、桃金娘、甘草、樟脑等植物中重要气味的组成部分。

Trans-Anethole Chemical Structure

CAS No. : 4180-23-8

规格	价格	是否有货
Free Sample (0.1-0.5 mg)		Apply now
10 mM * 1 mL in DMSO	￥550	In-stock
100 mg	￥500	In-stock
200 mg		询价
500 mg		询价

* Please select Quantity before adding items.

Trans-Anethole 相关产品

•相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Metabolism/Protease Compound Library
Natural Product Library
Anti-Cancer Compound Library
Human Endogenous Metabolite Compound Library
Fragment Library
Endocrinology Compound Library
Medicine Food Homology Compound Library
Traditional Chinese Medicine Monomer Library
Food Additive Library
Food-Sourced Compound Library
Inactive Ingredient Library

生物活性

Trans-Anethole ((E)-Anethole), a phenylpropene derivative isolated from Pimpinella, shows estrogenic activity at lower concentrations and cytotoxic at higher concentrations in cancer cell lines^[1]^[2]. Trans-Anethole ((E)-Anethole) contributes a large component of the odor and flavor of anise and fennel, anise myrtle, liquorice, camphor, magnolia blossoms, and star anise^[3].

IC₅₀ & Target

Human Endogenous Metabolite

分子量

148.20

Formula

C₁₀H₁₂O

CAS 号

4180-23-8

中文名称

反式茴香烯

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL (674.76 mM; Need ultrasonic)

H₂O : 1 mg/mL (6.75 mM; ultrasonic and warming and heat to 80°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	6.7476 mL	33.7382 mL	67.4764 mL
5 mM	1.3495 mL	6.7476 mL	13.4953 mL
10 mM	0.6748 mL	3.3738 mL	6.7476 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (16.87 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (16.87 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (16.87 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (16.87 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (16.87 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (16.87 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Tabanca N, et al. Estrogenic activity of isolated compounds and essential oils of Pimpinella species from Turkey, evaluated using a recombinant yeast screen. Planta Med. 2004 Aug;70(8):728-35.

[2]. Nakagawa Y, et al. Cytotoxic and xenoestrogenic effects via biotransformation of trans-anethole on isolated rat hepatocytes and cultured MCF-7 human breast cancer cells. Biochem Pharmacol. 2003 Jul 1;66(1):63-73.

[3]. Fahlbusch, et al. “Flavors and Fragrances”, Ullmann’s Encyclopedia of Industrial Chemistry, Weinheim: Wiley-VCH.

Astringin(Synonyms: 白皮杉醇葡萄糖苷; trans-Astringin)

发表于2024年4月26日由Whatman官网

天然产物糖类和糖苷 Saccharides and Glycosides

Astringin;(Synonyms: 白皮杉醇葡萄糖苷; trans-Astringin) 纯度: 97.39%

Astringin (trans-Astringin) 是一种天然糖苷，存在于云杉 (Picea sitchensis) 和挪威云杉 (Picea abies)，葡萄 (Vitis vinifera) 细胞培养物和葡萄酒中。Astringin 具有强大的抗氧化能力和癌症化学预防活性。

Astringin Chemical Structure

CAS No. : 29884-49-9

规格	价格	是否有货	数量
10;mM;*;1 mL in DMSO	￥2253	In-stock
5 mg	￥2520	In-stock
10 mg	￥4290	In-stock
50 mg	;	询价	;
100 mg	;	询价	;

* Please select Quantity before adding items.

Astringin 相关产品

bull;相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Natural Product Library
Anti-Cancer Compound Library
Glycoside Compound Library
Phenols Library
Traditional Chinese Medicine Monomer Library
Food-Sourced Compound Library

生物活性

Astringin (trans-Astringin) is a natural glycoside found in the bark of Picea sitchensis and Picea abies (Norway spruce), in Vitis vinifera cell cultures and in wine. Astringin has potent antioxidant capacity and cancer-chemopreventive activity^[1].

分子量

406.38

Formula

C₂₀H₂₂O₉

CAS 号

29884-49-9

中文名称

白皮杉醇葡萄糖苷

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20deg;C	3 years
	4deg;C	2 years
In solvent	-80deg;C	6 months
	-20deg;C	1 month

溶解性数据

In Vitro:;

DMSO : 125 mg/mL (307.59 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4608 mL	12.3038 mL	24.6075 mL
5 mM	0.4922 mL	2.4608 mL	4.9215 mL
10 mM	0.2461 mL	1.2304 mL	2.4608 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

Solubility: ≥ 1.25 mg/mL (3.08 mM); Clear solution

此方案可获得 ≥ 1.25 mg/mL (3.08 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 12.5 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

Solubility: ≥ 1.25 mg/mL (3.08 mM); Clear solution

此方案可获得 ≥ 1.25 mg/mL (3.08 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 12.5 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Le TK, et al. Highly regioselective hydroxylation of polydatin, a resveratrol glucoside, for one-step synthesis of astringin, a piceatannol glucoside, by P450 BM3. Enzyme Microb Technol. 2017 Feb;97:34-42.

N-p-trans-Coumaroyltyramine(Synonyms: N-反式对香豆酰基酪胺)

发表于2024年4月22日由Whatman官网

天然产物天然产物苯丙素类 Phenylpropanoids

N-p-trans-Coumaroyltyramine (Synonyms: N-反式对香豆酰基酪胺) 纯度: 98.78%

N-p-trans-Coumaroyltyramine 是一种从蓼属植物中分离出的 cinnamoylphenethyl amide，能作为乙酰胆碱酯酶 (AChE) 抑制剂，其 IC₅₀ 值为 122 μM。N-p-trans-Coumaroyltyramine 具有抗锥虫活性，对 T. brucei rhodesiense 作用的 IC₅₀ 值为 13.3 µM。

N-p-trans-Coumaroyltyramine Chemical Structure

CAS No. : 36417-86-4

规格	价格	是否有货
5 mg	￥3360	In-stock
10 mg	￥5710	In-stock
50 mg		询价
100 mg		询价

* Please select Quantity before adding items.

N-p-trans-Coumaroyltyramine 相关产品

•相关化合物库:

Covalent Screening Library Plus
Natural Product Library Plus
Bioactive Compound Library Plus
Anti-Infection Compound Library
Neuronal Signaling Compound Library
Natural Product Library
Covalent Screening Library
Phenols Library
Traditional Chinese Medicine Monomer Library
Anti-Alzheimer’s Disease Compound Library
Antiparasitic Compound library
Neurodegenerative Disease-related Compound Library
Food-Sourced Compound Library

生物活性

N-p-trans-Coumaroyltyramine is a cinnamoylphenethyl amide isolated from polygonum hyrcanicum, acts as an acetylcholinesterase (AChE) inhibitor with an an IC₅₀ of 122 μM. N-p-trans-Coumaroyltyramine exhibits anti-trypanosomal activity with an IC₅₀ of 13.3 µM for T. brucei rhodesiense^[1]^[2].

IC₅₀ & Target

IC50: 122 μM (AChE)^[2]

分子量

283.32

Formula

C₁₇H₁₇NO₃

CAS 号

36417-86-4

中文名称

N-反式对香豆酰基酪胺

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : 100 mg/mL (352.96 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.5296 mL	17.6479 mL	35.2958 mL
5 mM	0.7059 mL	3.5296 mL	7.0592 mL
10 mM	0.3530 mL	1.7648 mL	3.5296 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (8.82 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (8.82 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (8.82 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (8.82 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (8.82 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (8.82 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。

参考文献

[1]. Moradi-Afrapoli F, et al. Cinnamoylphenethyl amides from Polygonum hyrcanicum possess anti-trypanosomal activity. Nat Prod Commun. 2012 Jun;7(6):753-5.

[2]. Kim DK, et al. Inhibitory effect of trans-N-p-coumaroyl tryamine from the twigs of Celtis chinensis on the acetylcholinesterase. Arch Pharm Res. 2003 Sep;26(9):735-8.

N-trans-p-coumaroyloctopamine

发表于2024年3月29日由Whatman官网

天然产物天然产物苯丙素类 Phenylpropanoids

N-trans-p-coumaroyloctopamine

N-trans-p-coumaroyloctopamine 是从茄子(Solanum melongena L.) 中分离得到的一种苯丙醇胺。

N-trans-p-coumaroyloctopamine Chemical Structure

CAS No. : 66648-45-1

规格	价格	是否有货
1 mg	￥1250	询问价格 & 货期
5 mg	￥3150	询问价格 & 货期

* Please select Quantity before adding items.

生物活性	N-trans-p-coumaroyloctopamine is a phenylpropanoid amide isolated from eggplant (Solanum melongena L.)^[1].
分子量	299.32
Formula	C₁₇H₁₇NO₄
CAS 号	66648-45-1
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Sun J, et al. Characterization and quantitative analysis of phenylpropanoid amides in eggplant (Solanum melongena L.) by high performance liquid chromatography coupled with diode array detection and hybrid ion trap time-of-flight mass spectrometry. J Agric Food Chem. 2015 Apr 8;63(13):3426-36.

trans-Pterostilbene 品牌：Nagara Science

发表于2024年3月27日由Whatman官网

trans-Pterostilbene

品牌：Nagara Science
CAS No.：
储存条件：-20℃
纯度：>98%(HPLC)

产品编号 (生产商编号)	等级	规格	运输包装	零售价(RMB)	库存情况	参考值
NS300603	–	100 mg	–	咨询	–	–

* 干冰运输、大包装及大批量的产品需酌情添加运输费用

* 零售价、促销产品折扣、运输费用、库存情况、产品及包装规格可能因各种原因有所变动，恕不另行通知，确切详情请联系上海金畔生物科技有限公司。

Phytotech C283-25G trans-CINNAMIC ACID 肉桂酸（反式） 25G

发表于2024年3月27日由Whatman官网

上海金畔生物科技有限公司提供Phytotech C283-25G trans-CINNAMIC ACID 肉桂酸（反式） 25G，欢迎访问官网了解更多产品信息和订购

品牌货号产品名称规格价格

Phytotech C283-25G trans-CINNAMIC ACID 肉桂酸（反式） 25G 229.00

Phytotech F263-100G FERROUS SULFATE 硫酸亚铁 7水 100G 229.00

Phytotech N609-100G NIACINAMIDE 烟酰胺/尼克酰胺/维生素pp/维生素b3 100G 229.00

Phytotech X874-100MG X-GAL X-GAL 100MG 229.00

Phytotech C186-10G CALCIUM PANTOTHENATE 泛酸钙/维生素B5 10G 211.00

Phytotech E316-100G EDTA EDTA 100G 208.00

Phytotech M521-100G MAGNESIUM CHLORIDE 氯化镁 6水 100G 208.00

Phytotech G249-100ML GAMBORG VIT. POWDER (1000x) (1000x) B5培养基维生素 100ML 207.00

Phytotech M654-500ML M & S MACRONUTRIENT STOCK SOL MS大量元素储存液（10X） 500ML 204.00

Phytotech F320-10G MEDIA DYE, GREEN 色素绿 10G 189.00

Phytotech F321-10G MEDIA DYE, YELLOW 色素黄 10G 189.00

Phytotech F322-10G MEDIA DYE, BLUE 色素蓝 10G 189.00

Phytotech F323-10G MEDIA DYE, RED 色素红 10G 189.00

Phytotech M250-100G MANGANESE SULFATE 硫酸锰 1水 100G 189.00

Phytotech P730-100ML POTASSIUM CHLORIDE SOL. 3.0 M 氯化钾溶液 100ML 189.00

Phytotech T859-5G TETRACYCLINE HYDROCHLORIDE 盐酸四环素 5G 174.00

Phytotech A106-100G L-ASCORBIC ACID 维生素C/抗坏血酸 100G 170.00

Phytotech A126-1L ANTIOXIDANT MIXTURE 抗氧化剂 1L 170.00

Phytotech B800-5G 6-BENZYLAMINOPURINE (BA) 6-苄氨基嘌呤/6-BA 5G 170.00

Phytotech G362-15mL GIB ACID SOLUTION (13mg/mL) 赤霉素GA3溶液 15mL 170.00

trans-Chalcone(Synonyms: 反-查耳酮)

发表于2024年3月25日由Whatman官网

天然产物黄酮类 Flavonoids

trans-Chalcone (Synonyms: 反-查耳酮) 纯度: ≥97.0%

trans-Chalcone 是从Aronia melanocarpa 果皮中分离出来的，是类黄酮前体的双酚核心结构。trans-Chalcone 是有效的脂肪酸合酶 (FAS) 和 α-淀粉酶 (α-amylase) 抑制剂。trans-Chalcone 引起细胞周期停滞并诱导乳腺癌细胞系 MCF-7 凋亡。trans-Chalcone 具有抗真菌和抗癌活性。

trans-Chalcone Chemical Structure

CAS No. : 614-47-1

规格	价格	是否有货
10 mM * 1 mL in DMSO	￥550	In-stock
500 mg	￥500	In-stock
1 g		询价
5 g		询价

* Please select Quantity before adding items.

trans-Chalcone 相关产品

•相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Anti-Infection Compound Library
Apoptosis Compound Library
Immunology/Inflammation Compound Library
Metabolism/Protease Compound Library
Natural Product Library
Anti-Cancer Compound Library
Antifungal Compound Library
Traditional Chinese Medicine Monomer Library
Flavonoids Library
Anti-Cancer Metabolism Compound Library
Anti-Obesity Compound Library
Lipid Metabolism Compound Library

生物活性

trans-Chalcone, isolated from Aronia melanocarpa skin, is a biphenolic core structure of flavonoids precursor. trans-Chalcone is a potent fatty acid synthase (FAS) and α-amylase inhibitor. trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7. trans-Chalcone has antifungal and anticancer activity^[1]^[2]^[3].

体外研究
(In Vitro)

trans-Chalcone competitively inhibits porcine pancreatic α-amylase with a K_i of 48 μM^[2].
trans-Chalcone (30.23-98.03 μM; 24 hours) induces cell cycle arrest and apoptosis in MCF-7 cells^[1].
trans-Chalcone (20-80 μM; 24, 48 hours) reduces the expression of the apoptosis-related protein Bcl-2^[1].
trans-Chalcone (58.25 μM; 6, 24 hours) has greater inhibition of Bcl-2, induction of APAF1 and BAX, and strong induction of CIDEA in 24 hours^[1].
trans-Chalcone (24 hours) inhibits MCF-7 cell viability (IC₂₀=30.23 μM; IC₅₀=58.25 μM; IC₈₀=98.03 μM). trans-Chalcone (48 h) has IC₅₀s of 41.53 μM and 48.41 μM for MCF-7 and 3T3 cell lines, respectively. trans-Chalcone exhibits a pronounced cytotoxicity activity^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:	MCF-7 cell
Concentration:	30.23, 58.25, 98.03 μM
Incubation Time:	24 hours
Result:	Induced apoptosis of the breast cancer cell line.

Cell Cycle Analysis^[1]

Cell Line:	MCF-7 cell
Concentration:	30.23, 58.25, 98.03 μM
Incubation Time:	24 hours
Result:	Caused cell cycle arrest in G1.

Western Blot Analysis^[1]

Cell Line:	MCF-7 cell
Concentration:	20, 40, 80 μM
Incubation Time:	24, 48 hours
Result:	Reduced the expression of the apoptosis-related protein Bcl-2 and induced the expression of the CIDEA gene. There was marked degradation of cyclin D1 at 48 h.

RT-PCR^[1]

Cell Line:	MCF-7 cell
Concentration:	58.25 μM
Incubation Time:	6, 24 hours
Result:	Had greater inhibition of Bcl-2, induction of APAF1 and BAX, and strong induction of CIDEA in 24 hours.

分子量

208.26

Formula

C₁₅H₁₂O

CAS 号

614-47-1

中文名称

反-查耳酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL (480.17 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.8017 mL	24.0085 mL	48.0169 mL
5 mM	0.9603 mL	4.8017 mL	9.6034 mL
10 mM	0.4802 mL	2.4008 mL	4.8017 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (12.00 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (12.00 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (12.00 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (12.00 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (12.00 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (12.00 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。

参考文献

[1]. Luis Felipe Buso Bortolotto, et al. Cytotoxicity of trans-chalcone and licochalcone A against breast cancer cells is due to apoptosis induction and cell cycle arrest. Biomed Pharmacother. 2017 Jan;85:425-433.

[2]. Mahmoud Najafian, et al. Trans-chalcone: a novel small molecule inhibitor of mammalian alpha-amylase. Mol Biol Rep. 2011 Mar;38(3):1617-20.

[3]. Tamires Aparecida Bitencourt, et al. Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum. BMC Complement Altern Med. 2013 Sep 17;13:229.

Cytiva思拓凡-Whatman滤纸滤膜滤器

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标签归档：trans

β-Caryophyllene(Synonyms: β-石竹烯; (-)-(E)-Caryophyllene; (−)-β-caryophyllene; (−)-trans-Caryophyllene)

β-Caryophyllene 相关产品

•相关化合物库:

trans-Cinnamic acid(Synonyms: 反式肉桂酸; trans-3-Phenylacrylic acid)

trans-Cinnamic acid 相关产品

•相关化合物库:

trans-1,2-Cyclohexanediaminetetraacetic acid

trans-1,2-Cyclohexanediaminetetraacetic acid 相关产品

bull;相关化合物库:

Trans-Anethole(Synonyms: (E)-Anethole)

Trans-Anethole 相关产品

•相关化合物库:

Astringin(Synonyms: 白皮杉醇葡萄糖苷; trans-Astringin)

Astringin 相关产品

bull;相关化合物库:

N-p-trans-Coumaroyltyramine(Synonyms: N-反式对香豆酰基酪胺)

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