标签归档：blue

Disperse Blue 148(Synonyms: C.I. Disperse Blue 148 C.I. 11124)

发表于由

Disperse Blue 148;(Synonyms: C.I. Disperse Blue 148; C.I. 11124)

Disperse Blue 148是一种蓝色偶氮染料。

Disperse Blue 148amp;;(Synonyms: C.I. Disperse Blue 148; C.I. 11124)

Disperse Blue 148 Chemical Structure

CAS No. : 52239-04-0

规格 价格 是否有货
10;mM;*;1 mL in DMSO ￥880 询问价格 货期
100 mg ￥800 询问价格 货期

* Please select Quantity before adding items.

Disperse Blue 148 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus

生物活性

Disperse Blue 148 is the best high-temperature trichromatic blue azo dye. Target: Single-crystal structures of the best high-temperature trichromatic blue azo dye C.I. Disperse Blue 148 and its diazonium component 3-amino-5-nitro-[2,1]- benzisothiazole are described herein. C.I. Disperse Blue 148 exhibits an essentially coplanar molecular structure and a dimeric packing mode between adjacent phenyl and benzisothiazole rings. Particularly, PXRD measurement reveals the existence of a new crystalline form of C.I. Disperse Blue 148 having the highest melting point and the best thermal stability, which is obviously different from all the known α, β, and γ forms. [1]

分子量

413.45

Formula

C19H19N5O4S
CAS 号

52239-04-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)
溶解性数据
In Vitro:;

H2O : ≥ 30 mg/mL (72.56 mM)

DMSO : 20 mg/mL (48.37 mM; Need ultrasonic and warming)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4187 mL 12.0934 mL 24.1867 mL
5 mM 0.4837 mL 2.4187 mL 4.8373 mL
10 mM 0.2419 mL 1.2093 mL 2.4187 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Hui-Fen Qian, et al. Structural and spectral characterizations of C.I. Disperse Blue 148 having a new crystalline form. Dyes and Pigments Volume 99, Issue 2, November 2013, Pages 489-495

Brilliant blue G-250

发表于由

生化分析试剂 Biochemical Assay Reagents
Brilliant blue G-250;

Brilliant Blue G-250 是一种常用于 SDS-PAGE 分离蛋白质可视化的染料，染色过程简单，定量高。在 Bradford 蛋白质分析中，由于 Brilliant Blue G-250 与蛋白质结合，蛋白质浓度由 595 nm 处的吸光度确定。Brilliant Blue G-250 是一种安全、高选择性的 P2×7R 拮抗剂，有望使 NLRP3炎症体失活。

Brilliant blue G-250

Brilliant blue G-250 Chemical Structure

CAS No. : 6104-58-1

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

Brilliant Blue G-250 is a dye commonly used for the visualization of proteins separated by SDS-PAGE, offering a simple staining procedure and high quantitation. In the Bradford protein assay, protein concentrations are determined by the absorbance at 595 nm due to the binding of Brilliant Blue G-250 to proteins. Brilliant Blue G-250 is a safe highly selective P2×7R antagonist with promising consequent inactivation of NLRP3 inflammasome[1][2][3].

分子量

854.02

Formula

C47H48N3NaO7S2
CAS 号

6104-58-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, sealed storage, away from moisture

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
参考文献

  • [1]. Dyballa N, Metzger S. Fast and sensitive colloidal coomassie G-250 staining for proteins in polyacrylamide gels. J Vis Exp. 2009;(30):1431. Published 2009 Aug 3.

    [2]. Han XX, et al. Highly sensitive protein concentration assay over a wide range via surface-enhanced Raman scattering of Coomassie brilliant blue. Anal Chem. 2010;82(11):4325-4328.

    [3]. Zohny MH, et al. Coomassie brilliant blue G-250 dye attenuates bleomycin-induced lung fibrosis by regulating the NF-κB and NLRP3 crosstalk: A novel approach for filling an unmet medical need [published online ahead of print, 2022 Feb 21]. Biomed Pharmacother. 2022;148:112723.

Bio-Serv动物模型饲料K3293 Medium, Blue

发表于由

上海金畔生物科技有限公司代理Bio-Serv品牌动物模型饲料全线产品，欢迎访问官网了解更多产品信息。
Bio-Serv动物模型饲料K3293 Medium, Blue

K3293

K3294

K3295

Product Details
  • Blue Kong with attached welded link, stainless steel chain with quick link
    (overall chain length – approximately 5 1/2")
  • Fill with treats to promote mental and physical activity
  • Cagewasher safe
Dimensions
Kong Toy Medium – 3 1/2″ high
Kong Toy Large – 4″ high
Kong Toy XLarge – 5″ high
Chain Length – approximately 5 1/2″
Reviews
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Bio-Serv动物模型饲料K3283 Small, Blue

发表于由

上海金畔生物科技有限公司代理Bio-Serv品牌动物模型饲料全线产品，欢迎访问官网了解更多产品信息。
Bio-Serv动物模型饲料K3283 Small, Blue

K3283

K3284

K3285

K3287

Product Details
  • Made of natural rubber
  • Visible on radiographs
  • 25% stronger than regular Kongs
  • Fill with treats to promote mental and physical activity
  • Cagewasher safe
Dimensions
Small – 3″ high
Medium – 3 1/2″ high
Large – 4″ high
XLarge – 5″ high
King – 6″ high
Reviews
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250ml玻璃瓶,10/盒 GRADUATED BLUE SCREW bottles 250MLT_707FB800250

发表于由

250ml玻璃瓶,10/盒 GRADUATED BLUE SCREW bottles 250ML

简要描述：

产品简介

耐化学腐蚀，耐高温高压，无滴漏，多种规格可选
● 硼硅酸 3.3 玻璃材质，符合 USP EP 一类玻璃
● 热膨胀系数低，可高温高压灭菌（耐 140℃）
● 带刻度，白色瓷釉标记区，持久耐用
● 抗化学腐蚀性强，无析出，低渗透率
● 高度抛光表面，不易残留，易清洗
● 符合 ISO GL 45 螺口标准，兼容 ISO R115 和 DIN 168 标准
● 聚丙烯（PP）外旋盖，带 O 型防滴漏倾倒环，可替换

250ml玻璃瓶,10/盒 GRADUATED BLUE SCREW bottles 250ML

250ml玻璃瓶,10/盒 GRADUATED BLUE SCREW bottles 250MLT_707FB800250

500ml玻璃瓶,10/盒 GRADUATED BLUE SCREW bottles 500ML （T_707FB800500

发表于由

500ml玻璃瓶,10/盒 GRADUATED BLUE SCREW bottles 500ML （

简要描述：

耐化学腐蚀，耐高温高压，无滴漏，多种规格可选
● 硼硅酸 3.3 玻璃材质，符合 USP EP 一类玻璃
● 热膨胀系数低，可高温高压灭菌（耐 140℃）
● 带刻度，白色瓷釉标记区，持久耐用
● 抗化学腐蚀性强，无析出，低渗透率
● 高度抛光表面，不易残留，易清洗
● 符合 ISO GL 45 螺口标准，兼容 ISO R115 和 DIN 168 标准
● 聚丙烯（PP）外旋盖，带 O 型防滴漏倾倒环，可替换

500ml玻璃瓶,10/盒 GRADUATED BLUE SCREW bottles 500ML （T_707FB800500

Direct Blue 1(Synonyms: Chicago Sky Blue 6B)

发表于由

Direct Blue 1;(Synonyms: Chicago Sky Blue 6B) 纯度: ge;95.0%

Direct Blue 1 (Chicago Sky Blue 6B) 是免疫荧光组织化学中背景自体荧光的一种复染料。Direct Blue 1 在结构上与谷氨酸盐有关，是一种有效且具有竞争性的 VGLUT 抑制剂，不影响质膜转运体。Direct Blue 1 是第一个能够抑制 Aβ 结合的小分子 PrP 配体。

Direct Blue 1amp;;(Synonyms: Chicago Sky Blue 6B)

Direct Blue 1 Chemical Structure

CAS No. : 2610-05-1

规格 价格 是否有货 数量
10;mM;*;1 mL in DMSO ￥550 In-stock
500 mg ￥500 In-stock
1 g ; 询价 ;
5 g ; 询价 ;

* Please select Quantity before adding items.

Direct Blue 1 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus

生物活性

Direct Blue 1 (Chicago Sky Blue 6B) is a counterstain for background autofluorescence in immunofluorescence histochemistry. Direct Blue 1, structurally related to glutamate, is a potent and competitive VGLUT inhibitor without affecting plasma membrane transporters. Direct Blue 1 is the first small molecule PrP ligand capable of inhibiting Aβ binding[1].

分子量

992.80

Formula

C34H24N6Na4O16S4
CAS 号

2610-05-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, sealed storage, away from moisture

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

DMSO : 125 mg/mL (125.91 mM; Need ultrasonic)

H2O : 2.08 mg/mL (2.10 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.0073 mL 5.0363 mL 10.0725 mL
5 mM 0.2015 mL 1.0073 mL 2.0145 mL
10 mM 0.1007 mL 0.5036 mL 1.0073 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 4.17 mg/mL (4.20 mM); Clear solution

    此方案可获得 ≥ 4.17 mg/mL (4.20 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 41.7 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 4.17 mg/mL (4.20 mM); Clear solution

    此方案可获得 ≥ 4.17 mg/mL (4.20 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 41.7 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Lodha N, Poojary SA. A Novel Contrast Stain for the Rapid Diagnosis of Pityriasis Versicolor: A Comparison of Chicago Sky Blue 6B Stain, Potassium Hydroxide Mount and Culture. Indian J Dermatol. 2015;60(4):340-344.

    [2]. Yu G, et al. The antinociceptive effects of intracerebroventricular administration of Chicago sky blue 6B, a vesicular glutamate transporter inhibitor. Behav Pharmacol. 2013;24(8):653-658.

    [3]. Risse E, et al. Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay. J Biol Chem. 2015;290(27):17020-17028.

TMB(Synonyms: BM blue Sure Blue TMB)

发表于由

TMB;(Synonyms: BM blue; Sure Blue TMB) 纯度: 99.83%

TMB (BM blue) 是免疫组化和ELISA的显色底物。

TMBamp;;(Synonyms: BM blue; Sure Blue TMB)

TMB Chemical Structure

CAS No. : 54827-17-7

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
10;mM;*;1 mL in DMSO ￥550 In-stock
500 mg ￥400 In-stock
1 g ￥500 In-stock
5 g ￥1100 In-stock
10 g ; 询价 ;
50 g ; 询价 ;

* Please select Quantity before adding items.

TMB 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus

生物活性

TMB (BM blue) is a chromogenic substrate used in staining procedures in immunohistochemistry as well as being a visualising reagent used in enzyme-linked immunosorbent assays (ELISA).

分子量

240.34

Formula

C16H20N2
CAS 号

54827-17-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

DMSO : 100 mg/mL (416.08 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.1608 mL 20.8039 mL 41.6077 mL
5 mM 0.8322 mL 4.1608 mL 8.3215 mL
10 mM 0.4161 mL 2.0804 mL 4.1608 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

TMB monosulfate(Synonyms: BM blue monosulfate Sure Blue TMB monosulfate)

发表于由

TMB monosulfate;(Synonyms: BM blue monosulfate; Sure Blue TMB monosulfate) 纯度: 99.88%

TMB monosulfate是免疫组化和ELISA的显色底物。

TMB monosulfateamp;;(Synonyms: BM blue monosulfate; Sure Blue TMB monosulfate)

TMB monosulfate Chemical Structure

CAS No. : 54827-18-8

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
10;mM;*;1 mL in DMSO ￥550 In-stock
100 mg ￥500 In-stock
200 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

TMB monosulfate 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus

生物活性

TMB monosulfate is a chromogenic substrate used in staining procedures in immunohistochemistry as well as being a visualizing reagent used in enzyme-linked immunosorbent assays (ELISA).

分子量

338.42

Formula

C16H22N2O4S
CAS 号

54827-18-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, sealed storage, away from moisture

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

DMSO : ≥ 28 mg/mL (82.74 mM)

H2O : 2.78 mg/mL (8.21 mM; ultrasonic and warming and heat to 60°C)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9549 mL 14.7745 mL 29.5491 mL
5 mM 0.5910 mL 2.9549 mL 5.9098 mL
10 mM 0.2955 mL 1.4775 mL 2.9549 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

Leucomethylene blue mesylate(Synonyms: TRx0237 mesylate Methylene blue leuco base mesylate)

发表于由

Leucomethylene blue mesylate;(Synonyms: TRx0237 mesylate; Methylene blue leuco base mesylate) 纯度: 98.75%

Leucomethylene blue (TRx0237) mesylate 是具有口服活性的二代 tau 蛋白聚集的抑制剂 (Ki 值为0.12 μM)，可用于阿尔兹海默症的研究。Leucomethylene blue mesylate 是 Methylene blue (亚甲基蓝)的一种还原形式, 亚甲基蓝是一种化学指示剂和生物染色剂。

Leucomethylene blue mesylateamp;;(Synonyms: TRx0237 mesylate; Methylene blue leuco base mesylate)

Leucomethylene blue mesylate Chemical Structure

CAS No. : 1236208-20-0

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
10;mM;*;1 mL in DMSO ￥660 In-stock
5 mg ￥600 In-stock
10 mg ￥780 In-stock
50 mg ￥2300 In-stock
100 mg ￥4200 In-stock
200 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

Leucomethylene blue mesylate 相关产品

bull;相关化合物库:

  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Neuronal Signaling Compound Library
  • Clinical Compound Library
  • Drug Repurposing Compound Library
  • Orally Active Compound Library
  • Anti-Alzheimer’s Disease Compound Library
  • Neurodegenerative Disease-related Compound Library
  • Targeted Diversity Library

生物活性

Leucomethylene blue (TRx0237) mesylate, an orally active second-generation tau protein aggregation inhibitor (Ki of 0.12 μM), could be used for the study of Alzheimer’s Disease. Leucomethylene blue mesylate is a common reduced form of Methylene Blue, Methylene Blue is a member of the thiazine class of dyes[1][2][3].

IC50 Target

Ki: 0.12 μM (tau)[3].
体外研究
(In Vitro)

Leucomethylene blue (100 nM, 48 h) mesylate not only decreases the tau and p-tau expression levels, but also reversed the promoting effects of Aβ25-35 on orexin A and adenosine A1R expression levels[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: Human SH-SY5Y cell line.
Concentration: 100 nM.
Incubation Time: 48 h.
Result: Aβ25-35 and TRx 0237 co-treatment significantly reversed the promoting effects of Aβ25-35 on tau, p-tau, orexin A and adenosine A1R expression.

分子量

477.62

Formula

C18H27N3O6S3
CAS 号

1236208-20-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, stored under nitrogen, away from moisture

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (stored under nitrogen, away from moisture)
溶解性数据
In Vitro:;

DMSO : 110 mg/mL (230.31 mM; Need ultrasonic)

H2O : 83.33 mg/mL (174.47 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0937 mL 10.4686 mL 20.9371 mL
5 mM 0.4187 mL 2.0937 mL 4.1874 mL
10 mM 0.2094 mL 1.0469 mL 2.0937 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 7.5 mg/mL (15.70 mM); Clear solution

    此方案可获得 ≥ 7.5 mg/mL (15.70 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 75.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.75 mg/mL (5.76 mM); Clear solution

    此方案可获得 ≥ 2.75 mg/mL (5.76 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 27.5 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
*以上所有助溶剂都可在 MCE 网站选购。
参考文献

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    [2]. Zhenhua Liu, et al. Amyloid β and tau are involved in sleep disorder in Alzheimer’s disease by orexin A and adenosine A(1) receptor. Int J Mol Med. 2019 Jan;43(1):435-442.

    [3]. Francesco Panza, et al. Tau aggregation inhibitors: the future of Alzheimer’s pharmacotherapy? Expert Opin Pharmacother. 2016;17(4):457-61.