标签归档：货期

Peptide 401

发表于由

Peptide 401;

Peptide 401 是一种有效的来源于蜂毒中的肥大细胞脱颗粒肽，抑制血管通透性。

Peptide 401amp;;

Peptide 401 Chemical Structure

CAS No. : 32908-73-9

规格 价格 是否有货
500 μg ￥2800 询问价格 货期
1 mg ￥4800 询问价格 货期
5 mg ￥16500 询问价格 货期

* Please select Quantity before adding items.

生物活性

Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).

IC50 Target

serotonin

;

Histamine Receptor

;

体内研究
(In Vivo)

Peptide 401 substantially inhibits the oedema provoked by subplantar injection of carrageenin or intra-articular injection of turpentine in the rat. The ED50 of 401 is c. 0.1 mg/kg. The anti-inflammatory effect is assessed by measurement of the increased 125I-albumin content of an injected site in comparison with an uninjected contralateral site. Peptide 401 also suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, bradykinin, 5-hydroxytryptamine (5-HT), and prostaglandins)[1]. Peptide 401 (MCD peptide) contains 22 residues and occurs in the venom of the common European honey bee to the extent of about 2% by weight . It has powerful anti-inflammatory activity (at doses as low as 0.1 mg/kg) in a variety of animal models, i.e., hind paw oedema in the rat induced by carrageenin or turpentine, adjuvant arthritis in the rat, and increased skin permeability in the rat resulting from subcutaneous injection of bradykinin, prostaglandin E1 kallikrein, histamine and 5- hydroxytryptamine (5-HT). It has a powerful degranulating effect on mast cells and involves the release of histamine and other pharmacologically active agents[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2587.22

Formula

C110H192N40O24S4
CAS 号

32908-73-9
Sequence

Ile-Lys-Cys-Asn-Cys-Lys-Arg-His-Val-Ile-Lys-Pro-His-Ile-Cys-Arg-Lys-Ile-Cys-Gly-Lys-Asn-NH2 (Disulfide bridge: Cys3-Cys15, Cys5-Cys19)
Sequence Shortening

IKCNCKRHVIKPHICRKICGKN-NH2 (Disulfide bridge: Cys3-Cys15, Cys5-Cys19)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 50 mg/mL (19.33 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.3865 mL 1.9326 mL 3.8652 mL
5 mM 0.0773 mL 0.3865 mL 0.7730 mL
10 mM 0.0387 mL 0.1933 mL 0.3865 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Hanson JM, et al. Anti-inflammatory property of 401 (MCD-peptide), a peptide from the venom of the bee Apis mellifera (L.). Br J Pharmacol. 1974 Mar;50(3):383-92.

    [2]. Banks BE, et al. Anti-inflammatory activity of bee venom peptide 401 (mast cell degranulating peptide) andcompound 48/80 results from mast cell degranulation in vivo. Br J Pharmacol. 1990 Feb;99(2):350-4.

Isocolumbin

发表于由

上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。

Isocolumbin 

Isocolumbin 是从Jateorhiza palmate Miers (Colombo root) 分离得到的一种二萜。

Isocolumbin

Isocolumbin Chemical Structure

CAS No. : 471-54-5

规格 价格 是否有货
1 mg ￥1200 询问价格 & 货期
5 mg ￥3000 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Isocolumbin is a diterpenoid isolated from Jateorhiza palmate Miers (Colombo root)[1].

分子量

358.39

Formula

C20H22O6
CAS 号

471-54-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Michiko Yonemitsu, et al. Studies on the Constituents of Jateorhiza palmata Miers (Colombo root), I Separation and Structure of a New Furanoid Diterpene Glucoside (Palmatoside A). Liebigs Annalen der Chemie. 1986 Aug.

Mauritianin

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Mauritianin;

Mauritianin是一种从 Acalypha indica 花和叶中分离出来的山奈酚。Mauritianin 为拓扑异构酶 I 抑制剂。

Mauritianin

Mauritianin Chemical Structure

CAS No. : 109008-28-8

规格 价格 是否有货
5 mg ￥4900 询问价格 货期
10 mg ￥8200 询问价格 货期

* Please select Quantity before adding items.

生物活性

Mauritianin is a kaempferol glycoside isolated from the flowers and leaves of Acalypha indica. Mauritianin is a topoisomerase I inhibitor[1][2].

IC50 Target

Topoisomerase I[2]
分子量

740.66

Formula

C33H40O19
CAS 号

109008-28-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Nahrstedt A, et al. Flavonoids from Acalypha indica. Fitoterapia. 2006 Sep;77(6):484-6.

    [2]. Ma J, et al. DNA topoisomerase I inhibitors from Rinorea anguifera. Bioorg Med Chem Lett. 2005 Feb 1;15(3):813-6.

Syntide 2

发表于由

Syntide 2;

Syntide 2 是一种 Ca2+– 和钙调蛋白 (CaM) 依赖性蛋白激酶 II (CaMKII) 底物肽，选择性地抑制赤霉素 (GA) 反应，使组成和脱落酸调节事件不受影响。

Syntide 2amp;;

Syntide 2 Chemical Structure

CAS No. : 108334-68-5

规格 价格 是否有货
1 mg ￥850 询问价格 货期
5 mg ￥3000 询问价格 货期
10 mg ￥5000 询问价格 货期

* Please select Quantity before adding items.

Syntide 2 的其他形式现货产品:

Syntide 2 TFA

生物活性

Syntide 2, a Ca2+– and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected[1].

IC50 Target

Ca2+

;

CaMKII

;

分子量

1507.82

Formula

C68H122N20O18
CAS 号

108334-68-5
Sequence

Pro-Leu-Ala-Arg-Thr-Leu-Ser-Val-Ala-Gly-Leu-Pro-Gly-Lys-Lys
Sequence Shortening

PLARTLSVAGLPGKK
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Ritchie S, et al. Calcium-Dependent Protein Phosphorylation May Mediate the Gibberellic Acid Response in Barley Aleurone. Plant Physiol. 1998 Feb 1;116(2):765-76.

Epitalon(Synonyms: Epithalon Epithalamin)

发表于由

Epitalon;(Synonyms: Epithalon; Epithalamin)

Epitalon 是一种抗衰老剂和端粒酶激活剂。Epitalon 对小鼠自发性肿瘤的发展具有抑制作用，具有 geroprotective 作用，通过鼻内给药可增加神经元活性。Epitalon 可用于癌症，衰老和色素性视网膜炎。

Epitalonamp;;(Synonyms: Epithalon; Epithalamin)

Epitalon Chemical Structure

CAS No. : 307297-39-8

规格 价格 是否有货
1 mg ￥650 询问价格 货期
5 mg ￥1950 询问价格 货期
10 mg ￥3500 询问价格 货期
25 mg ￥7500 询问价格 货期

* Please select Quantity before adding items.

Epitalon 的其他形式现货产品:

Epitalon TFA

生物活性

Epitalon is an anti-aging agent and a telomerase activator. Epitalon has an inhibitory effect of the on the development of spontaneous tumors in mice, has geroprotective actions and intranasal administration increases neuronal activity. Epitalon can be used for cancer, old age and Retinitis Pigmentosa[1].

体外研究
(In Vitro)

Addition of Epithalon peptide in telomerase-negative human fetal fibroblast culture induced expression of the catalytical subunit, enzymatic activity of telomerase, and telomere elongation, which can be due to reactivation of telomerase gene in somatic cells and indicates the possibility of prolonging life span of a cell population and of the whole organism[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Epitalon increases the lifespan of mice and fruit flies and restores the circadian rhythms of melatonin and cortisol production in old rhesus monkeys. At the same time, Epitalon prolongs the functional integrity of the eye retina in Campbell rats with hereditary Retinitis Pigmentosa and improves the visual functions in patients with pigmental retinal degeneration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

390.35

Formula

C14H22N4O9
CAS 号

307297-39-8
Sequence Shortening

AEDG
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Khavinson VKh. et al. Peptides and Ageing. Neuro Endocrinol Lett. 2002;23 Suppl 3:11-144.

    [2]. Vanhee C, et al. Identification of the small research tetra peptide Epitalon, assumed to be a potential treatment for cancer, old age and Retinitis Pigmentosa in two illegal pharmaceutical preparations. Drug Test Anal. 2015 Mar;7(3):259-64.

    [3]. Khavinson VKh, et al. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003 Jun;135(6):590-2.

LAH4

发表于由

LAH4;

LAH4 是两亲性肽抗生素的 α 螺旋，具有强大的抗菌 (antimicrobial)、核酸转染(nucleic acid transfection) 和细胞渗透活性。LAH4 具有较高的质粒 DNA 传递能力。LAH4 对细菌膜外膜中的阴离子脂质有很强的亲和力。

LAH4amp;;

LAH4 Chemical Structure

CAS No. : 184776-51-0

规格 价格 是否有货
1 mg ￥2500 询问价格 货期
5 mg ￥5800 询问价格 货期
10 mg ￥9600 询问价格 货期

* Please select Quantity before adding items.

LAH4 的其他形式现货产品:

LAH4 TFA

生物活性

LAH4, an alpha-helix of the designed amphipathic peptide antibiotic, exhibits potent antimicrobial, nucleic acid transfection and cell penetration activities. LAH4 possesses high plasmid DNA delivery capacities. LAH4 has a strong affinity for anionic lipids found in the outer membrane of bacterial membranes[1][2][3].

体外研究
(In Vitro)

LAH4 is capable of complexing DNA, associating with the cell surfacemembrane and then, when enveloped within an endosome, disrupts the endosomal membrane as the pH drops[1].
LAH4 possesses robust plasmid DNA transfection properties. Peptides of the LAH4 family are able to efficiently deliver siRNAs in vitro into a human cell line[2].
LAH4 is found to mediate the intracellular delivery of both protein and nucleotide cargo and facilitate protein internalization using mechanisms involving endosomal acidification and processing through the proteasome pathway, leading to enhanced cross presentation of protein antigen by dendritic cells to CD8+ T cells. LAH4 also improves the internalization of CpG, resulting in NF-kB activation, thus potentiating the adjuvant effect of CpG[3].
LAH4 exhibits antibiotic activities against Escherichia coli and Bacillus subtilis. the peptide does not, however, lyse human red blood cells at bacteriocidal concentrations. The antibiotic activities of LAH4 are 2 orders of magnitude more pronounced at pH 5 when compared with pH 7.5[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2779.53

Formula

C132H228N38O27
CAS 号

184776-51-0
Sequence

Lys-Lys-Ala-Leu-Leu-Ala-Leu-Ala-Leu-His-His-Leu-Ala-His-Leu-Ala-Leu-His-Leu-Ala-Leu-Ala-Leu-Lys-Lys-Ala
Sequence Shortening

KKALLALALHHLAHLALHLALALKKA
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Mason AJ, et al. The antibiotic and DNA-transfecting peptide LAH4 selectively associates with, and disorders, anionic lipids in mixed membranes. FASEB J. 2006;20(2):320-322.

    [2]. Langlet-Bertin B, et al. Design and evaluation of histidine-rich amphipathic peptides for siRNA delivery. Pharm Res. 2010;27(7):1426-1436.

    [3]. Zhang TT, et al. LAH4 enhances CD8+ T cell immunity of protein/peptide-based vaccines. Vaccine. 2012;30(4):784-793.

    [4]. Vogt TC, et al. The interactions of histidine-containing amphipathic helical peptide antibiotics with lipid bilayers. The effects of charges and pH. J Biol Chem. 1999;274(41):29115-29121.

GRGDSP

发表于由

GRGDSP;

GRGDSP 是一种合成的线性RGD肽，是一种整联蛋白 (integrin) 抑制剂。

GRGDSPamp;;

GRGDSP Chemical Structure

CAS No. : 91037-75-1

规格 价格 是否有货
5 mg ￥1600 询问价格 货期
10 mg ￥2900 询问价格 货期
25 mg ￥6400 询问价格 货期

* Please select Quantity before adding items.

GRGDSP 的其他形式现货产品:

GRGDSP TFA

生物活性

GRGDSP, a synthetic linear RGD peptide, is an integrin inhibitor.

IC50 Target

Integrin[1]
体外研究
(In Vitro)

It is demonstrated that transarterial infusion of GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro integrin-inhibitor which includes RGD-peptide). As a synthetic linear RGD peptide, GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro) can inhibit the adherence of tumor cells to endothelial cells of blood vessels and limit its metastasis[1]. GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro) is used as a soluble integrin-blocking RGD-based peptide. GRGDSP is used widely together with other RGD peptides in integrin research. GRGDSP can be used to modify the surface of cardiovascular implants such as vascular grafts to promote endothelialization[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

587.58

Formula

C22H37N9O10
CAS 号

91037-75-1
Sequence

Gly-Arg-Gly-Asp-Ser-Pro
Sequence Shortening

GRGDSP
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Qian J, et al. Transarterial administration of integrin inhibitor loaded nanoparticles combined with transarterial chemoembolization for treating hepatocellular carcinoma in a rat model. World J Gastroenterol. 2016 Jun 7;22(21):5042-9.

    [2]. Patel S, et al. Regulation of endothelial cell function by GRGDSP peptide grafted on interpenetrating polymers. J Biomed Mater Res A. 2007 Nov;83(2):423-33.

Secologanoside

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Secologanoside;

Secologanoside 是从 Poraqueiba sericea 中分离得到的萜类化合物，对弹性蛋白酶 (elastase) 具有低抑制活性，IC50 值为 164 μg/mL。Secologanoside 对成纤维细胞有中度细胞毒性。

Secologanoside

Secologanoside Chemical Structure

CAS No. : 59472-23-0

规格 价格 是否有货
5 mg ￥2690 询问价格 货期
10 mg ￥4570 询问价格 货期

* Please select Quantity before adding items.

生物活性

Secologanoside is a triterpenoid isolated from Poraqueiba sericea, weakly inhibits elastase with an IC50 of 164 μg/mL. Secologanoside is moderate cytotoxic to fibroblasts[1].

分子量

390.34

Formula

C16H22O11
CAS 号

59472-23-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zebiri I, et al. Biological activities of triterpenoids from Poraqueiba sericea stems. Nat Prod Res. 2017 Jun;31(11):1333-1338.

Etelcalcetide(Synonyms: AMG 416 KAI-4169)

发表于由

Etelcalcetide;(Synonyms: AMG 416; KAI-4169)

Etelcalcetide (AMG 416) 是一种合成肽，有钙敏感受体 (CaSR) 活化剂的作用。Etelcalcetide 可有效降低接受血液透析的继发性甲状旁腺功能亢进患者的 甲状旁腺激素 (PTH) 浓度。

Etelcalcetideamp;;(Synonyms: AMG 416; KAI-4169)

Etelcalcetide Chemical Structure

CAS No. : 1262780-97-1

规格 价格 是否有货
1 mg ￥550 询问价格 货期
5 mg ￥2000 询问价格 货期
10 mg ￥3400 询问价格 货期
25 mg ￥6800 询问价格 货期

* Please select Quantity before adding items.

Etelcalcetide 的其他形式现货产品:

Etelcalcetide hydrochloride

生物活性

Etelcalcetide (AMG 416) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis[1].

Clinical Trial

分子量

1048.25

Formula

C38H73N21O10S2
CAS 号

1262780-97-1
Sequence Shortening

C1′ . Ac-{d-Cys1}-{d-Ala}-{d-Arg}-{d-Arg}-{d-Arg}-{d-Ala}-{d-Arg}-NH2 (Disulfide bridge: Cys1′-Cys1)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Block GA, et al. Effect of Etelcalcetide vs Cinacalcet on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: A Randomized Clinical Trial. JAMA. 2017 Jan 10;317(2):156-164.

GsMTx4

发表于由

GsMTx4;

GsMTx4 是一种蜘蛛毒液肽，选择性地抑制属于 Piezo 和 TRP 通道家族的阳离子可渗透的机械敏感性通道(MSCs)。GsMTx4 是一种重要的药理学工具，用于鉴定兴奋性 MSCs 在正常生理学和病理学中的作用。GsMTx4 显着减弱膀胱机能亢进。

GsMTx4amp;;

GsMTx4 Chemical Structure

CAS No. : 1209500-46-8

规格 价格 是否有货
500 μg ￥2700 询问价格 货期
1 mg ￥5000 询问价格 货期
5 mg ￥18000 询问价格 货期

* Please select Quantity before adding items.

GsMTx4 的其他形式现货产品:

GsMTx4 TFA

生物活性

GsMTx4 is a spider venom peptide that selectively inhibits cation-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology[1]. GsMTx4 significantly attenuates bladder hyperactivity[2].

IC50 Target

MSCs[1]
分子量

4101.89

Formula

C185H279N49O45S6
CAS 号

1209500-46-8
Sequence Shortening

GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Gnanasambandam R, et al. GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels. Biophys J. 2017 Jan 10;112(1):31-45.

    [2]. Liu Q, et al. Increased Piezo1 channel activity in interstitial Cajal-like cells induces bladder hyperactivity by functionally interacting with NCX1 in rats with cyclophosphamide-induced cystitis. Exp Mol Med. 2018 May 7;50(5):60.