标签归档：aminosidine

Paromomycin sulfate(Synonyms: 硫酸巴龙霉素; Aminosidine sulfate)

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天然产物 糖类和糖苷 Saccharides and Glycosides

Paromomycin sulfate;(Synonyms: 硫酸巴龙霉素; Aminosidine sulfate) 纯度: ge;98.0%

Paromomycin (Aminosidine) sulfate 是一种的广谱氨基糖苷类抗生素 (antibiotic)，具有杀螨杀菌作用，是新霉素 (HY-B0470) 衍生物。Paromomycin sulfate 通过与细菌 30S 核糖体 A 位点的 RNA 寡核苷酸特异性结合，使 mRNA 的翻译提前终止，并抑制蛋白质合成。Paromomycin sulfate 可用于细菌和寄生虫感染的研究。

Paromomycin sulfate(Synonyms: 硫酸巴龙霉素; Aminosidine sulfate)

Paromomycin sulfate Chemical Structure

CAS No. : 1263-89-4

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg) ; Apply now ;
10;mM;*;1 mL in Water ￥500 In-stock
500 mg ￥400 In-stock
1 g ￥500 In-stock
5 g ; 询价 ;
10 g ; 询价 ;

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生物活性

Paromomycin (Aminosidine) sulfate, a neomycin (HY-B0470) derivative, is a broad spectrum aminoglycoside antibiotic with amebicidal and bactericidal effects. Paromomycin sulfate prematures termination of translation of mRNA and inhibits protein synthesis by specifically binds to the RNA oligonucleotide at the A site of bacterial 30S ribosomes. Paromomycin sulfate can be used for the research of bacterial and parasitic infections[1][2][3].

体外研究
(In Vitro)

Paromomycin sulfate (500 μg/ml) reduces intracellular parasitic forms by 97.2% compared to control in Caco-2 cells and reduces the percentage of intracellular C. parvum forms by 99.5% in HCT-8 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Paromomycin sulfate (oral gavage; 50 mg/kg-200 mg/kg; once daily; for five consecutive days two weeks post infection) reduces the number of oocyst per gram of feces and intestine. It shows minimal focal inflammation in only 20% of the sections at 50 mg/kg from the intestines of mice infected with C. parvum and only 10% of focal inflammation at 200 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss albino mice[1]
Dosage: 50 mg/kg-200 mg/kg
Administration: Oral gavage; 50 mg/kg-200 mg/kg; once daily; for five consecutive days two weeks post infection
Result: Was against cryptosporidiosis in vivo.

Clinical Trial

分子量

713.71

Formula

C23H47N5O18S
CAS 号

1263-89-4
中文名称

硫酸巴龙霉素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4deg;C, sealed storage, away from moisture

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 100 mg/mL (140.11 mM; ultrasonic and warming and heat to 80°C)

Ethanol : 1 mg/mL (1.40 mM; Need ultrasonic)

DMSO : 1 mg/mL (1.40 mM; ultrasonic and warming and heat to 80°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.4011 mL 7.0056 mL 14.0113 mL
5 mM 0.2802 mL 1.4011 mL 2.8023 mL
10 mM 0.1401 mL 0.7006 mL 1.4011 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Tony J Tavares, et al. Structure of the cytosine-cytosine mismatch in the thymidylate synthase mRNA binding site and analysis of its interaction with the aminoglycoside paromomycin. RNA. 2009 May;15(5):911-22.

    [2]. Mohamed Mammeri, et al. Efficacy of chitosan, a natural polysaccharide, against Cryptosporidium parvum in vitro and in vivo in neonatal mice. Exp Parasitol. 2018 Nov;194:1-8.

    [3]. Ibrahim Aly, et al. Efficacy of Low and High Dose of Paromomycin Sulfate for Treatment of Cryptosporidiosis in Immunosuppressed Infected-Mice.Global Veterinaria 15 (2): 137-143, 2015